Immunohistochemical localization of neurokinin-1 receptor in the lumbar spinal cord of young rats

Morphology and distribution

Erika Polgár, Péter Szücs, László Urbán, Klára Matesz, I. Nagy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The type and distribution of neurokinin-1 (NK-1) receptor-expressing neurones were studied in young (14-day-old) rats' lumbar spinal cord using pre-embedding immunohistochemistry. The heaviest immunoreactivity was observed in the middle part and lateral fourth of lamina I where the great majority of immunoreactive perikarya represented fusiform and multipolar cells. In lamina II the middle and medial part showed moderate immunoreactivity, most of the cells resembled stalked cells. In lamina III the labelled perikarya were evenly distributed, while those in lamina IV accumulated mainly in the lateral part. In both laminae most of the labelled neurones represented central cells, the rest of them belonged to the antenna-type cells with long dorsally directed dendrites penetrating the superficial laminae. The immunoreactivity in laminae V-VII was uniform and relatively weak. In lamina VIII the immunopositive perikarya were encountered only rarely while in lamina IX virtually all motoneurones showed weak immunoreactivity. Lamina X contained small, multipolar and fusiform labelled perikarya. In conclusion, we found that the general appearance of the NK-1 receptor immunostaining and the major type of NK-1 receptor-expressing neurones were similar to that found previously in adult spinal cord. Using the same method as Brown and colleagues the number of labelled NK-1 receptor immunoreactive cells was similar in young and adult animals except lamina I where the number of immunoreactive neurones was twice that in adults.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalSomatosensory and Motor Research
Volume16
Issue number4
Publication statusPublished - 1999

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Neurokinin-1 Receptors
Spinal Cord
Neurons
Substantia Gelatinosa
Motor Neurons
Dendrites
Young Adult
Immunohistochemistry
Spinal Cord Dorsal Horn

Keywords

  • Immunohistochemistry
  • NK-1 receptor
  • Rat
  • Spinal cord

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Immunohistochemical localization of neurokinin-1 receptor in the lumbar spinal cord of young rats : Morphology and distribution. / Polgár, Erika; Szücs, Péter; Urbán, László; Matesz, Klára; Nagy, I.

In: Somatosensory and Motor Research, Vol. 16, No. 4, 1999, p. 361-368.

Research output: Contribution to journalArticle

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