Immunohistochemical localization of atrial natriuretic peptide in primary aldosteronism

Z. Schaff, K. Racz, J. Gutkowska, O. Sergev, R. Kiss, I. Varga, Z. Szabo, B. Szende, K. Lapis, J. Feher, E. Glaz

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Abstract

Using the immunoperoxidase method with specific antibody we examined the presence of atrial natriuretic peptide (ANP) in adrenal tissues of a patient with primary aldosteronism and those derived from a patient with Cushing's syndrome. We found cells immunopositive for ANP in primary aldosteronism but not in Cushing's syndrome. In primary aldosteronism, we noted positively stained cells mainly but not exclusively in the adenomatous tissue. These results demonstrate for the first time the presence of immunoreactive ANP in adrenal tissues of a patient with primary aldosteronism and suggest that adrenal ANP may have potentially important impacts on aldosterone secretion in this disorder.

Original languageEnglish
Pages (from-to)229-242
Number of pages14
JournalJournal of Experimental Pathology
Volume3
Issue number3
Publication statusPublished - Dec 1 1987

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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