Immunohistochemical features and staging of early gastric cancer

Simona Gurzu, Janina Orlowska, Haruhiko Sugimura, Tivadar Bara, Z. Szentirmay, Wladyslaw Januszewicz, Tivadar Jr Bara, Janos Szederjesi, Ioan Jung

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Abstract

Introduction: The aim of this study was to analyze the particularities of early gastric cancer (EGC) and their importance for staging, prognosis, and therapy. Material and methods: A total of 338 GCs diagnosed and surgically removed in three medical institutes from Eastern Europe were retrospectively examined, and the EGCs were further examined. Besides the demographic factors and tumor characteristics, immunostains were performed with E-cadherin, HER-2, p53, Ki67, MLH-1, MSH-2, COX-2, VEGF-A, CD31, and CD105. Results: From the 338 GCs, 29 were EGCs, the average being similar in Poland and Hungary (12.37% and 13.33% respectively) but lower in Romania (5.61%). The rate of lymph node metastases was 20.69% (n = 6). Two of the cases presented liver metastases, both of them having a multifocal aspect. In 1 of these cases, limited to the mucosa, intramural carcinomatosis of the lymph vessels was seen in submucosa, muscularis propria, and subserosa. COX-2 positivity was observed in 14 (48.72%) cases. COX-2 was directly correlated with microvessel density determined with CD31 (p < 0.001) and CD105 (p = 0.03). Same correlation with CD31 and CD105 was seen for HER-2 (p = 0.03 and p = 0.0007). The only negative independent prognostic factors for overall survival were tumor localization at the proximal stomach and male gender, regardless of age. Conclusions: In EGCs, intramural carcinomatosis of the lymph vessels and multifocality should be separately described in every surgical pathology report, as indicators of aggressiveness. Microsatellite status, E-cadherin, HER-2, p53, and Ki67 do not have prognostic value in EGC, but the highly angiogenic pattern is a possible therapeutic target.

Original languageEnglish
Pages (from-to)1373-1382
Number of pages10
JournalArchives of Medical Science
Volume13
Issue number6
DOIs
Publication statusPublished - Jan 1 2017

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Cadherins
Stomach Neoplasms
Lymph
Neoplasm Metastasis
Melanocyte-Stimulating Hormones
Carcinoma
Eastern Europe
Romania
Surgical Pathology
Hungary
Poland
Microvessels
Microsatellite Repeats
Vascular Endothelial Growth Factor A
Neoplasms
Stomach
Mucous Membrane
Lymph Nodes
Demography
Liver

Keywords

  • Angiogenesis
  • Carcinomatosis
  • Carcinomatous lymphangitis.
  • Early gastric cancer
  • Staging

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gurzu, S., Orlowska, J., Sugimura, H., Bara, T., Szentirmay, Z., Januszewicz, W., ... Jung, I. (2017). Immunohistochemical features and staging of early gastric cancer. Archives of Medical Science, 13(6), 1373-1382. https://doi.org/10.5114/aoms.2016.58665

Immunohistochemical features and staging of early gastric cancer. / Gurzu, Simona; Orlowska, Janina; Sugimura, Haruhiko; Bara, Tivadar; Szentirmay, Z.; Januszewicz, Wladyslaw; Bara, Tivadar Jr; Szederjesi, Janos; Jung, Ioan.

In: Archives of Medical Science, Vol. 13, No. 6, 01.01.2017, p. 1373-1382.

Research output: Contribution to journalArticle

Gurzu, S, Orlowska, J, Sugimura, H, Bara, T, Szentirmay, Z, Januszewicz, W, Bara, TJ, Szederjesi, J & Jung, I 2017, 'Immunohistochemical features and staging of early gastric cancer', Archives of Medical Science, vol. 13, no. 6, pp. 1373-1382. https://doi.org/10.5114/aoms.2016.58665
Gurzu, Simona ; Orlowska, Janina ; Sugimura, Haruhiko ; Bara, Tivadar ; Szentirmay, Z. ; Januszewicz, Wladyslaw ; Bara, Tivadar Jr ; Szederjesi, Janos ; Jung, Ioan. / Immunohistochemical features and staging of early gastric cancer. In: Archives of Medical Science. 2017 ; Vol. 13, No. 6. pp. 1373-1382.
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AU - Januszewicz, Wladyslaw

AU - Bara, Tivadar Jr

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KW - Carcinomatous lymphangitis.

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