Immunohistochemical detection of arteriolar hyperplasia in canine liver biopsy samples using the claudin-5 antibody

Csaba Jakab, M. Rusvai, Péter Gálfi, Ágnes Szabára, Zoltán Szabó, J. Kulka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Claudins are key tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, which are responsible for the permeability of the paracellular space. This paper describes that the endothelial cells of normal hepatic arterioles, portal venules and portal lymphatics as well as the endothelium of sinusoids from dogs show strong membranous claudin-5 cross-reactivity. In 25 liver biopsy samples taken from dogs with portal vein hypoperfusion, an increased number of arterioles was detected in the portal areas (PAs) by the use of humanised anti-claudin-5 antibody. The increased number of hyperplastic hepatic arterioles per PA was 5-6, 8-12 and 15-20 in the case of small, medium-sized and large PAs, respectively. It is suggested that the claudin-5 marker can improve the detection of hepatic arteriolar proliferation in the PAs of liver samples.

Original languageEnglish
Pages (from-to)423-430
Number of pages8
JournalActa Veterinaria Hungarica
Volume58
Issue number4
DOIs
Publication statusPublished - Dec 1 2010

Fingerprint

Claudin-5
hyperplasia
Hyperplasia
Canidae
biopsy
Biopsy
Arterioles
liver
antibodies
Antibodies
dogs
Liver
endothelial cells
sampling
Endothelial Cells
Claudins
Dogs
Lymphatic Vessels
portal vein
Portal Vein

Keywords

  • Arteriolar hyperplasia
  • biopsy
  • claudin-5
  • dog
  • immunohistochemistry
  • liver

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Immunohistochemical detection of arteriolar hyperplasia in canine liver biopsy samples using the claudin-5 antibody. / Jakab, Csaba; Rusvai, M.; Gálfi, Péter; Szabára, Ágnes; Szabó, Zoltán; Kulka, J.

In: Acta Veterinaria Hungarica, Vol. 58, No. 4, 01.12.2010, p. 423-430.

Research output: Contribution to journalArticle

Jakab, Csaba ; Rusvai, M. ; Gálfi, Péter ; Szabára, Ágnes ; Szabó, Zoltán ; Kulka, J. / Immunohistochemical detection of arteriolar hyperplasia in canine liver biopsy samples using the claudin-5 antibody. In: Acta Veterinaria Hungarica. 2010 ; Vol. 58, No. 4. pp. 423-430.
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