Kutyák immunhaemolyticus anaemiája

Szemlecikk és esetismertetés

Translated title of the contribution: Immunohaemolytic anaemia of dogs review and case report

Máthé Ákos, K. Vörös, Vajdovich Péter, Kótai István, Soós Pál

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Immunohaemolytic anaemia (IHA) is a frequently diagnosed haematological disease of dogs. It is characterised by premature destruction of erythrocytes mediated by antibodies, with or without complement. Based on the type of immunological factors and erythrocyte damage IHA is classified into five groups (Table 1). The authors summarise the clinical findings, diagnostic possibilities and treatment protocols of IHA based on recent literature data. They emphasise the importance of including IHA in the differential diagnosis of haemolytic disease in Hungary, where babesiosis is common. Two typical cases of the disease are presented to demonstrate the clinical features of IHA. Major clinical signs of IHA consist of pale mucous membranes, icterus, fever, tachycardia and dyspnoea. Haematology shows regenerative anaemia and neutrophilic leukocytosis. Diagnosis is based on detecting spherocytes and autoagglutination in the blood smear (Figure 1), or performing an osmotic fragility test (Table 2 and Figure 2). A positive Coombs-test is considered supportive of the diagnosis. Urinalysis reveals bilirubinuria and sometimes haemoglobinuria. Glucocorticoids are the first choice of treatment, but cytotoxic agents like azathioprine and cyclophosphamide have also been suggested. Supportive care should include heparin when autoagglutination is present and blood transfusion if the severity of anaemia is life threatening. The seasonal pattern of the disease in Hungary was similar as experienced by authors in other countries. IHA similarly to babesiosis was more frequently encountered during spring and autumn (Figure 3). In one of the presented cases clinical signs compatible with cold agglutinin disease are described. In this dog necrosis of the ear margins (Figure 4) and toes (Figure 5) occurred a few weeks after initial presentation. In the authors experience aspiration cytology of the spleen and liver could support the diagnosis of IHA by detecting spherocytes, red blood cell phagocytosis, bilirubin and haemosiderin pigments in macrophages.

Original languageHungarian
Pages (from-to)261-267
Number of pages7
JournalMagyar Allatorvosok Lapja
Volume120
Issue number5
Publication statusPublished - 1998

Fingerprint

anemia
Dogs
case studies
dogs
Spherocytes
Babesiosis
Hungary
Erythrocytes
erythrocytes
babesiosis
Anemia
Hemoglobinuria
Osmotic Fragility
Hemosiderin
Coombs Test
Cytophagocytosis
Autoimmune Hemolytic Anemia
immunologic factors
Urinalysis
Immuno-hemolytic anemia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Ákos, M., Vörös, K., Péter, V., István, K., & Pál, S. (1998). Kutyák immunhaemolyticus anaemiája: Szemlecikk és esetismertetés. Magyar Allatorvosok Lapja, 120(5), 261-267.

Kutyák immunhaemolyticus anaemiája : Szemlecikk és esetismertetés. / Ákos, Máthé; Vörös, K.; Péter, Vajdovich; István, Kótai; Pál, Soós.

In: Magyar Allatorvosok Lapja, Vol. 120, No. 5, 1998, p. 261-267.

Research output: Contribution to journalArticle

Ákos, M, Vörös, K, Péter, V, István, K & Pál, S 1998, 'Kutyák immunhaemolyticus anaemiája: Szemlecikk és esetismertetés', Magyar Allatorvosok Lapja, vol. 120, no. 5, pp. 261-267.
Ákos, Máthé ; Vörös, K. ; Péter, Vajdovich ; István, Kótai ; Pál, Soós. / Kutyák immunhaemolyticus anaemiája : Szemlecikk és esetismertetés. In: Magyar Allatorvosok Lapja. 1998 ; Vol. 120, No. 5. pp. 261-267.
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