Sera of patients with chronic liver disease were studied for the concentrations of IgG, IgA, IgM, ceruloplasmin, α 2 macroglobulin, β 1 C globulin and transferrin by the radial immunodiffusion procedure, and also for the titers of humoral antibodies reacting with nuclear, mitochondrial and soluble protein antigens from allogeneic liver by the passive hemagglutination method, and finally for Australia antigen and for its antibody titer by a microcomplement fixation procedure. In chronic persistent hepatitis the IgA and IgM levels, and in chronic aggressive hepatitis and in cirrhosis of the liver those of all three immunoglobulins showed a significant increase as compared with the controls. In chronic aggressive hepatitis, the increase in IgG was particularly marked. The serum ceruloplasmin and α 2 macroglobulin levels were increased in relation to the extent of the inflammatory process involving the hepatic stroma. In contrast, β 1 C globulin and transferrin were not significantly affected. Australia antigen and humoral antibodies were encountered most frequently in chronic aggressive hepatitis.
|Number of pages||7|
|Journal||Acta Medica Academiae Scientiarum Hungaricae|
|Publication status||Published - 1973|
ASJC Scopus subject areas