Immunoglobulins, glycoproteids and Australia antigen in chronic liver disease

J. Fehér, L. Jakab, I. Szilvasi

Research output: Contribution to journalArticle

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Abstract

Sera of patients with chronic liver disease were studied for the concentrations of IgG, IgA, IgM, ceruloplasmin, α 2 macroglobulin, β 1 C globulin and transferrin by the radial immunodiffusion procedure, and also for the titers of humoral antibodies reacting with nuclear, mitochondrial and soluble protein antigens from allogeneic liver by the passive hemagglutination method, and finally for Australia antigen and for its antibody titer by a microcomplement fixation procedure. In chronic persistent hepatitis the IgA and IgM levels, and in chronic aggressive hepatitis and in cirrhosis of the liver those of all three immunoglobulins showed a significant increase as compared with the controls. In chronic aggressive hepatitis, the increase in IgG was particularly marked. The serum ceruloplasmin and α 2 macroglobulin levels were increased in relation to the extent of the inflammatory process involving the hepatic stroma. In contrast, β 1 C globulin and transferrin were not significantly affected. Australia antigen and humoral antibodies were encountered most frequently in chronic aggressive hepatitis.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalActa Medica Academiae Scientiarum Hungaricae
Volume30
Issue number3
Publication statusPublished - 1973

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Chronic Hepatitis
Hepatitis B Surface Antigens
Immunoglobulins
Liver Diseases
Chronic Disease
Macroglobulins
Ceruloplasmin
Globulins
Transferrin
Immunoglobulin A
Immunoglobulin M
Antibodies
Immunoglobulin G
Immunodiffusion
Liver
Mitochondrial Proteins
Hemagglutination
Serum
Liver Cirrhosis
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Immunoglobulins, glycoproteids and Australia antigen in chronic liver disease. / Fehér, J.; Jakab, L.; Szilvasi, I.

In: Acta Medica Academiae Scientiarum Hungaricae, Vol. 30, No. 3, 1973, p. 197-203.

Research output: Contribution to journalArticle

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