Immunoelectron microscopic localization of the p21 protein in HT1080 human fibrosarcoma cell lines with altered N-ras gene expression.

J. Tímár, H. Paterson

Research output: Contribution to journalArticle

Abstract

The cellular localization of the p21 protein was studied by immunoelectron microscopy in human fibrosarcoma cells with different N-ras gene expression. The tumorigenic HT1080 cells--expressing equally the normal and mutant N-ras genes--contained the p21 in the plasma membrane, in pinocytotic areas as well as in the intracellular vesicles. The non-tumorigenic revertants--expressing more normal N-ras gene than the mutant one--contained p21 in the plasma membrane, especially at the cell junctions. These results suggest, that the mutant p21 may locate to the membrane areas connected with pino- or endocytotic functions.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalActa microbiologica Hungarica
Volume39
Issue number4
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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