Immunocytochemical localization of mG1uR1a metabotropic glutamate receptor in inhibitory interneurons of the cerebellar cortex

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Abstract

Immunocytochemical investigation of metabotrop glutamate receptor la in the cerebellar cortex of rat revealed a presence of this receptor in all cortical inhibitory nerve cells (Purkinje, basket, stellate, Lugaro and Golgi). In addition to the previously described localization of this receptor in Purkinje dendritic spines supplied by parallel and climbing fibres and considered to be responsible for cerebellar long-term depression, we have observed metabotropic glutamate receptor la immunopositivity also in the synapses between parallel fibres and dendrites of basket, stellate and Golgi neurons. The postsynaptic receptor was also present occasionally in inhibitory synapses between stellate cell axons and Purkinje cells as well as between Purkinje axon collaterals and Lugaro cell dendrites. The possibility, that mG1uR1a receptors in basket, Golgi and stellate cells might directly or indirectly contribute to cerebellar LTD, is discussed.

Original languageEnglish
Pages (from-to)181-194
Number of pages14
JournalActa biologica Hungarica
Volume47
Issue number1-4
Publication statusPublished - Dec 1 1996

Keywords

  • Cerebellar cortex
  • Imnunocytochemistry
  • Metabotrop glutamate receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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