Immuno-regulierende Peptide, I. Synthesen und Struktur-Aktivitüts-Beziehungen der Analoga des Thymopentins

Lajos Kisfaludy, Olga Nyéki, István Schön, Lászlö Denes, Julia Ember, László Szporny, Gyürgy Hajos, Béla Szende

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28 Citations (Scopus)


Seventeen peptides, related to thymopoietin pentapeptide, L-arginyl-L-lysyl-L-aspartyl-L-valyl-L-tyrosine (thymopentin) were synthesized by the stepwise strategy in solution. Of these, L-arginyl-L-lysyl-L-aspartic acid and L-arginyl-L-lysyl-L-aspartyl-L-valine, shortened from the C-terminus of the pentapeptide, exhibit significant immuno-stimulating potencies, exceeding those of thymopentin, both in vitro and in vivo immunological tests. Studies on the structure-activity relationships suggest that the potencial active site of thymopoietins is very sensitive to the N- and C-terminal elongations of the peptide chain. For thymic hormones, an active site carrying cumulative chemical signals is proposed instead of well-defined active centers.

Original languageEnglish
Pages (from-to)933-940
Number of pages8
JournalHoppe-Seyler's Zeitschrift fur Physiologische Chemie
Issue number2
Publication statusPublished - Jan 1 1983



  • IgM production
  • Immuno-stimulating peptides
  • cumulative chemical signals
  • structure-activity relationships
  • Å-rosette formation

ASJC Scopus subject areas

  • Biochemistry

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