Immunity, inflammation and cancer: A leading role for adenosine

Luca Antonioli, Corrado Blandizzi, Pál Pacher, György Haskó

Research output: Contribution to journalReview article

327 Citations (Scopus)

Abstract

Cancer is a complex disease that is dictated by both cancer cell-intrinsic and cell-extrinsic processes. Adenosine is an ancient extracellular signalling molecule that can regulate almost all aspects of tissue function. As such, several studies have recently highlighted a crucial role for adenosine signalling in regulating the various aspects of cell-intrinsic and cell-extrinsic processes of cancer development. This Review critically discusses the role of adenosine and its receptors in regulating the complex interplay among immune, inflammatory, endothelial and cancer cells during the course of neoplastic disease.

Original languageEnglish
Pages (from-to)842-857
Number of pages16
JournalNature Reviews Cancer
Volume13
Issue number12
DOIs
Publication statusPublished - Nov 14 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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