Dyspepsiás és pepticus fekélybetegek Helicobacter pylori-ellenes specifikus IgG, IgA és anti-CagA IgG immunválasza.

Translated title of the contribution: Immune responses of IgG, IgA and anti-CagA IgG to Helicobacter pylori in dyspeptic and peptic ulcer patients

K. Tamássy, P. Auli, B. Fekete, C. Antonello

Research output: Contribution to journalArticle

Abstract

The anti-H. pylori IgG, IgA, and anti CagA responses in dyspeptic patients have been evaluated. Of 481 patients 76% tested positive for IgG anti-H. pylori, 57% for anti-CagA, and 52% IgA for anti H. pylori. There was a significant age-related increase in IgG anti-H. pylori and IgA anti-H. Pylori prevalence, whereas anti-CagA positives were unreliable in this respect. The IgG seropositivity was the highest (93%) in duodenal ulcers (DU), 82% in antral gastritis and/or bulbitis (AG +/- /B), and 71% in gastric ulcer (GU). GU patients compared with DU and AG +/- /B ones tended to have the highest IgA anti-H. pylori prevalence (78% vs. 66% and 61%). The anti-CagA seropositivity was the most pronounced (80%) in DU followed by GU (72%) and AG +/- /B (68%). It is suggested that the serodiagnosis including IgG, IgA anti-H. pylori and anti-CagA determinations can not replace endoscopy in revealing the exact nature of gastroduodenal lesions. IgA anti-H. pylori determination in female patients with GU can be a valuable diagnostic tool. It is stated that in Hungary the prevalence of CagA positive H. pylori strains in anti-H. pylori IgG positive dyspeptic patients is 85%.

Original languageHungarian
Pages (from-to)985-988
Number of pages4
JournalOrvosi Hetilap
Volume138
Issue number16
Publication statusPublished - Apr 20 1997

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Peptic Ulcer
Helicobacter pylori
Immunoglobulin A
Immunoglobulin G
Stomach Ulcer
Duodenal Ulcer
anti-IgG
Hungary
Pylorus
Serologic Tests
Gastritis
Endoscopy
anti-IgA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dyspepsiás és pepticus fekélybetegek Helicobacter pylori-ellenes specifikus IgG, IgA és anti-CagA IgG immunválasza. / Tamássy, K.; Auli, P.; Fekete, B.; Antonello, C.

In: Orvosi Hetilap, Vol. 138, No. 16, 20.04.1997, p. 985-988.

Research output: Contribution to journalArticle

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