Immune response to Rauscher virus-induced leukemia in DBA mice. II. Correlation between antigenic expression and pathogenesis

F. Tóth, L. Vaczi

Research output: Contribution to journalArticle

Abstract

Previous studies have demonstrated that the Rauscher virus induces a biphasic erythroleukemia in DBA mice, and the regression of the disease is connected with the appearance of antibody-dependent cellular cytotoxicity. In the present work, attempts were made to reveal the mechanism leading to the lethal exacerbation of the leukemia. In the sera of leukemic mice soluble tumor-specific antigen could be demonstrated in the stages of early progression and regression but not in the stage of exacerbation. The antigen was present in form of immune complexes with free antibodies in excess. The emergence of a new population of leukemia cells has been observed during the stage of regression. On the surface of these cells the antigen receptor sites were masked by sialic acid which resulted in the loss of immunosensitivity and immunogenicity.

Original languageEnglish
Pages (from-to)265-272
Number of pages8
JournalNeoplasma
Volume25
Issue number3
Publication statusPublished - 1978

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Rauscher Virus
Inbred DBA Mouse
Leukemia
Leukemia, Erythroblastic, Acute
Antigen Receptors
Antibodies
N-Acetylneuraminic Acid
Neoplasm Antigens
Antigen-Antibody Complex
Antigens
Serum
Population

ASJC Scopus subject areas

  • Cancer Research

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Immune response to Rauscher virus-induced leukemia in DBA mice. II. Correlation between antigenic expression and pathogenesis. / Tóth, F.; Vaczi, L.

In: Neoplasma, Vol. 25, No. 3, 1978, p. 265-272.

Research output: Contribution to journalArticle

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