Immune response to rauscher virus induced leukemia in DBA mice I. Role of cellular and humoral immunity in spontaneous regression

F. D. Tóth, Sz Gomba, L. Váczi, M. Kása, J. Jakó

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DBA/1 and DBA/2 mice infected with the Rauscher leukemia virus developed a biphasic erythroleukemia. Transitory regression of the disease was closely associated with the appearance of tumorspecific antibodies and the exacerbation was preceded by the gradual decrease of antibody titer. The antibody dependent cellular cytotoxicity could be detected earlier, than the complement dependent cytotoxicity. Moreover, in each case the titer of antibody dependent cellular cytotoxicity was higher than that of complement dependent cytotoxicity. The results suggest that the antibody dependent cellular toxicity is mainly responsible for the rejection of tumor cells.

Original languageEnglish
Pages (from-to)471-481
Number of pages11
Issue number5
Publication statusPublished - Dec 1 1976


ASJC Scopus subject areas

  • Cancer Research

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