Immune dysregulation diseases

Shinsaku Imashuku, Melinda Erdős, Waleed Al-Herz, Mohammad Hassan Bemanian, Hirokazu Kanegane, László Maródi, Payam Mohammadinejad, Sergio D. Rosenzweig, Asghar Aghamohammadi

Research output: Chapter in Book/Report/Conference proceedingChapter


The main task of immune system is to protect the body against infections. When an antigen is recognized as a nonself by the immune system, a highly dynamic cascade of reactions will begin which includes both innate and adaptive immune responses. These mechanisms should be firmly controlled because exaggerated response to foreign antigens and/or improper response against self-antigens can result in autoimmunity. Various cells and mediator molecules are involved in the regulation of immune system. The complexity of this system makes it prone to many genetic defects resulting in increased susceptibility to infections and/or autoimmune disorders.

Original languageEnglish
Title of host publicationClinical Cases in Primary Immunodeficiency Diseases
Subtitle of host publicationA Problem-Solving Approach
PublisherSpringer Berlin Heidelberg
Number of pages45
ISBN (Electronic)9783642317859
ISBN (Print)9783642317842
Publication statusPublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Imashuku, S., Erdős, M., Al-Herz, W., Bemanian, M. H., Kanegane, H., Maródi, L., Mohammadinejad, P., Rosenzweig, S. D., & Aghamohammadi, A. (2012). Immune dysregulation diseases. In Clinical Cases in Primary Immunodeficiency Diseases: A Problem-Solving Approach (pp. 233-277). Springer Berlin Heidelberg.