Abstract
During the last 30 years more than 700 patients with systemic lupus erythematosus (SLE) have been treated in our department with their data analyzed. Here we focus on circulating immune complex (CIC) and its clearance. We demonstrated, microscopically, that the uptake of IgG sensitized erythrocytes (EA), via monocytes (Mo) of SLE patients, was elevated and correlated with the high CIC content. The in Vivo clearance of sensitized autolog E, and the in vitro degradation rate of soluble IC by Mo of SLE patients were decreased. This discrepancy could be explained by the molecular heterogeneity of FcγR being recognized lately. The high FcγRI expression and the low FcγRII and FcγRIII expression were detected by monoclonal antibodies (mAb) on Mo in SLE. The EA bound mostly to FcγRI, FcγRII and FcγRIII have a role in phagocytosis. The decreased receptor expression and function correlated with the disease activity and renal involvement. The shedding of receptors may cause a decrease on Mo surface, with the soluble FcRII and FcγRIII levels being elevated in serum of SLE patients. The mannose binding receptors, which play a role in the phagocytosis of apoptotic cells in SLE, were also decreased on Mo of SLE patients.
| Original language | English |
|---|---|
| Pages (from-to) | 497-502 |
| Number of pages | 6 |
| Journal | Autoimmunity Reviews |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Aug 2007 |
Fingerprint
Keywords
- Clearance
- Fcγ receptors
- Immune complex
- Monocytes
- SLE
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Immune complex clearance by monocytes and macrophages in systemic lupus erythematosus. / Kavai, Maria; Szegedi, G.
In: Autoimmunity Reviews, Vol. 6, No. 7, 08.2007, p. 497-502.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immune complex clearance by monocytes and macrophages in systemic lupus erythematosus
AU - Kavai, Maria
AU - Szegedi, G.
PY - 2007/8
Y1 - 2007/8
N2 - During the last 30 years more than 700 patients with systemic lupus erythematosus (SLE) have been treated in our department with their data analyzed. Here we focus on circulating immune complex (CIC) and its clearance. We demonstrated, microscopically, that the uptake of IgG sensitized erythrocytes (EA), via monocytes (Mo) of SLE patients, was elevated and correlated with the high CIC content. The in Vivo clearance of sensitized autolog E, and the in vitro degradation rate of soluble IC by Mo of SLE patients were decreased. This discrepancy could be explained by the molecular heterogeneity of FcγR being recognized lately. The high FcγRI expression and the low FcγRII and FcγRIII expression were detected by monoclonal antibodies (mAb) on Mo in SLE. The EA bound mostly to FcγRI, FcγRII and FcγRIII have a role in phagocytosis. The decreased receptor expression and function correlated with the disease activity and renal involvement. The shedding of receptors may cause a decrease on Mo surface, with the soluble FcRII and FcγRIII levels being elevated in serum of SLE patients. The mannose binding receptors, which play a role in the phagocytosis of apoptotic cells in SLE, were also decreased on Mo of SLE patients.
AB - During the last 30 years more than 700 patients with systemic lupus erythematosus (SLE) have been treated in our department with their data analyzed. Here we focus on circulating immune complex (CIC) and its clearance. We demonstrated, microscopically, that the uptake of IgG sensitized erythrocytes (EA), via monocytes (Mo) of SLE patients, was elevated and correlated with the high CIC content. The in Vivo clearance of sensitized autolog E, and the in vitro degradation rate of soluble IC by Mo of SLE patients were decreased. This discrepancy could be explained by the molecular heterogeneity of FcγR being recognized lately. The high FcγRI expression and the low FcγRII and FcγRIII expression were detected by monoclonal antibodies (mAb) on Mo in SLE. The EA bound mostly to FcγRI, FcγRII and FcγRIII have a role in phagocytosis. The decreased receptor expression and function correlated with the disease activity and renal involvement. The shedding of receptors may cause a decrease on Mo surface, with the soluble FcRII and FcγRIII levels being elevated in serum of SLE patients. The mannose binding receptors, which play a role in the phagocytosis of apoptotic cells in SLE, were also decreased on Mo of SLE patients.
KW - Clearance
KW - Fcγ receptors
KW - Immune complex
KW - Monocytes
KW - SLE
UR - http://www.scopus.com/inward/record.url?scp=34447518990&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447518990&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2007.01.017
DO - 10.1016/j.autrev.2007.01.017
M3 - Article
C2 - 17643939
AN - SCOPUS:34447518990
VL - 6
SP - 497
EP - 502
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 7
ER -