Immune checkpoint molecules in reproductive immunology

Eva Miko, Matyas Meggyes, Katalin Doba, Aliz Barakonyi, Laszlo Szereday

Research output: Contribution to journalReview article

8 Citations (Scopus)


Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity, transplantation, and tumor immune evasion. Maternal-fetal immunotolerance represents a real immunological challenge for the immune system of the mother: beside acceptance of the semiallogeneic fetus, the maternal immune system has to be prepared for immune defense mostly against infections. In this particular situation, the role of immune checkpoint molecules could be of special interest. In this review, we describe current knowledge on the role of immune checkpoint molecules in reproductive immunology.

Original languageEnglish
Article number846
JournalFrontiers in immunology
Issue numberAPR
Publication statusPublished - 2019


  • CTLA-4
  • Immune checkpoint molecule
  • Immunotolerance
  • PD-1
  • Pregnancy
  • Reproductive immunology
  • TIM-3

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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