Immune cell subsets, cytokine and cortisol levels during the first week of life in neonates born to pre-eclamptic mothers

Florentina Sava, Gergely Toldi, András Treszl, J. Hajdú, Ágnes Harmath, J. Rigó, T. Tulassay, B. Vásárhelyi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Problem: To address the hypothesis that pre-eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre-term newborns of PE mothers. Method of study: Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre-term infants affected by PE and 14 non-PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry. Results: The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates. Conclusion: Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.

Original languageEnglish
JournalAmerican Journal of Reproductive Immunology
DOIs
Publication statusAccepted/In press - 2017

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Pre-Eclampsia
Hydrocortisone
Mothers
Newborn Infant
Cytokines
Pregnancy
Eclampsia
Fetal Blood
Immunoassay
Immune System
Flow Cytometry
T-Lymphocytes

Keywords

  • CD4
  • Cortisol
  • HLA-DR
  • Memory T cell
  • Pre-eclampsia
  • Pre-term neonate

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

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title = "Immune cell subsets, cytokine and cortisol levels during the first week of life in neonates born to pre-eclamptic mothers",
abstract = "Problem: To address the hypothesis that pre-eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre-term newborns of PE mothers. Method of study: Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre-term infants affected by PE and 14 non-PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry. Results: The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates. Conclusion: Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.",
keywords = "CD4, Cortisol, HLA-DR, Memory T cell, Pre-eclampsia, Pre-term neonate",
author = "Florentina Sava and Gergely Toldi and Andr{\'a}s Treszl and J. Hajd{\'u} and {\'A}gnes Harmath and J. Rig{\'o} and T. Tulassay and B. V{\'a}s{\'a}rhelyi",
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T1 - Immune cell subsets, cytokine and cortisol levels during the first week of life in neonates born to pre-eclamptic mothers

AU - Sava, Florentina

AU - Toldi, Gergely

AU - Treszl, András

AU - Hajdú, J.

AU - Harmath, Ágnes

AU - Rigó, J.

AU - Tulassay, T.

AU - Vásárhelyi, B.

PY - 2017

Y1 - 2017

N2 - Problem: To address the hypothesis that pre-eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre-term newborns of PE mothers. Method of study: Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre-term infants affected by PE and 14 non-PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry. Results: The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates. Conclusion: Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.

AB - Problem: To address the hypothesis that pre-eclampsia (PE) impacts the fetal immune system, we investigated the prevalence of distinct immune cell subsets along with plasma cortisol and cytokine levels in pre-term newborns of PE mothers. Method of study: Cord blood and peripheral blood samples on the 1st, 3rd and 7th postnatal days of life were collected from 14 pre-term infants affected by PE and 14 non-PE pregnancies. We measured plasma cortisol and cytokine levels with immunoassays and assessed the prevalence of T, NK and DC subsets using flow cytometry. Results: The prevalence of CD4+ cells was lower in PE infants, while that of memory T cells was higher. Myeloid DCs had a lower prevalence in PE neonates. Cytokine and cortisol levels were lower in PE neonates. Conclusion: Our observations show that PE pregnancies are associated with altered newborn immune status during the first week of life.

KW - CD4

KW - Cortisol

KW - HLA-DR

KW - Memory T cell

KW - Pre-eclampsia

KW - Pre-term neonate

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