Immune cell profiling in intraplacental and postmolar choriocarcinomas

Zoltan Nagymanyoki, Michael J. Callahan, Mana M. Parast, Vilmos Fulop, Samuel C. Mok, Ross S. Berkowitz

Research output: Contribution to journalArticle

2 Citations (Scopus)


OBJECTIVE: To determine the level of infiltration and antigen profile of immune cells and explore their relationship in intraplacental and postmolar choriocarcinoma to better understand the immunobiology of choriocarcinoma. STUDY DESIGN: Immunolocalization of CD8, Granzyme B (GrB) and FoxP3 was performed on sections prepared from 5 intraplacental and 7 postmolar choriocarcinomas to characterize effector Tc cells (GrB+, CD8+) and GrB- (GrB-, CD8+) Tc cells, GrB+ NK cells (GrB+, CD8-) and Treg (FoxP3+) cells. RESULTS: In the case of intraplacental choriocarcinoma, immune cell infiltration was not detected in the surrounding villi or in the tumor. Immune cell infiltration into the implantation site of the placenta with intraplacental choriocarcinoma did not differ from that into thenormal pregnancy implantation site. In postmolar choriocarcinoma the immune cell infiltration of the adjacent tissue was vigorous and involved all types of immune cells (Tc, NK, Treg). In 6 of 7 cases of postmolar choriocarcinoma, in spite of the vigorous immune response, immune cells could not be seen in the choriocarcinoma tissue. A sharp infiltration border of immune cells was noted at the edge of the postmolar choriocarcinoma tissue. CONCLUSION: Intraplacental choriocarcinoma is not associated with a vigorous immune cell response. In contrast, vostmolar choriocarcinoma is associated with a vigorous immune cell response in adjacent tissues but not the choriocarcinoma tissue itself.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number8
Publication statusPublished - Aug 1 2008


  • Choriocarcinoma
  • Gestational trophoblastic disease
  • Natural killer cells
  • T-lymphocytes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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    Nagymanyoki, Z., Callahan, M. J., Parast, M. M., Fulop, V., Mok, S. C., & Berkowitz, R. S. (2008). Immune cell profiling in intraplacental and postmolar choriocarcinomas. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 53(8), 558-564.