Immobilization techniques for mono- and oligosaccharide microarrays

Alex Monzo, A. Guttman

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mono- and oligosaccharide microarrays play an essential role in the analysis of many important biological processes, such as DNA - sugar interactions, protein-sugar interactions, and sugar - sugar interactions. Based on the earlier success of DNA and protein microarrays, similar technologies emerged in the past years for sugar immobilization in order to fabricate carbohydrate microarrays. Efficient immobilization of various mono- and oligosaccharides of interest onto solid surfaces is indispensable for successful preparation of carbohydrate microarrays. In this paper, we review the different techniques available for covalent and noncovalent immobilization of conjugated and nonconjugated simple and complex sugars onto a palette of various surfaces. We also give a short overview on some of the future prospects of this emerging field.

Original languageEnglish
Pages (from-to)1033-1038
Number of pages6
JournalQSAR and Combinatorial Science
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Oligosaccharides
Monosaccharides
Microarrays
Sugars
Microarray
Immobilization
Carbohydrates
Biological Phenomena
Protein Array Analysis
Oligonucleotide Array Sequence Analysis
DNA
Interaction
Technology
Proteins
Protein
Preparation

Keywords

  • Covalent immobilization
  • Microarray
  • Monosaccharides
  • Noncovalent immobilization
  • Oligosaccharides

ASJC Scopus subject areas

  • Discrete Mathematics and Combinatorics
  • Pharmacology

Cite this

Immobilization techniques for mono- and oligosaccharide microarrays. / Monzo, Alex; Guttman, A.

In: QSAR and Combinatorial Science, Vol. 25, No. 11, 11.2006, p. 1033-1038.

Research output: Contribution to journalArticle

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