Immobilization stress-induced increase in plasma catecholamine levels is inhibited by a prolactoliberin (Salsolinol) administration

I. Bodnár, Boris Mravec, Lucia Kubovcakova, M. Fekete, Gyorgy M. Nagy, Richard Kvetnansky

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Catecholamines (CAs) are significantly involved in the regulation of homeostasis of the organism at rest and especially during stressful situations. Stress induces increases in plasma CA (epinephrine and norepinephrine) levels and prolactin (PRL) release from the adenopituitary. We have recently observed that salsolinol, which is produced by the neuro-intermediate lobe of the pituitary gland and by the hypothalamus, can selectively release PRL. Salsolinol is therefore considered to be a putative endogenous PRL-releasing factor. Based on the similarity of CA and PRL responses to stressors, we investigated whether salsolinol plays a role in the regulation of plasma CA levels at rest and of CA release induced by immobilization stress (IMO). Salsolinol did not affect CA baseline levels; however, it did inhibit IMO-induced CA release. Thus, the present study shows for the first time that salsolinol is not only a PRL-releasing factor but is also a potent inhibitor of stress-induced release of epinephrine and norepinephrine.

Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1018
DOIs
Publication statusPublished - 2004

Fingerprint

Immobilization
Catecholamines
Prolactin
Plasmas
Intermediate Pituitary Gland
Epinephrine
Norepinephrine
salsolinol
Plasma
Hypothalamus
Homeostasis

Keywords

  • Epinephrine
  • Immobilization stress
  • Norepinephrine
  • Plasma catecholamines
  • Prolactoliberin
  • Salsolinol

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Immobilization stress-induced increase in plasma catecholamine levels is inhibited by a prolactoliberin (Salsolinol) administration. / Bodnár, I.; Mravec, Boris; Kubovcakova, Lucia; Fekete, M.; Nagy, Gyorgy M.; Kvetnansky, Richard.

In: Annals of the New York Academy of Sciences, Vol. 1018, 2004, p. 124-130.

Research output: Contribution to journalArticle

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AU - Nagy, Gyorgy M.

AU - Kvetnansky, Richard

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