Immimohistochemical findings in jejunal specimens from patients with IgA deficiency

T. Klemola, E. Savilahti, A. Arató, T. Örmälä, J. Partanen, C. Eland, S. Koskimies

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Jejunal biopsy specimens from 25 patients with IgA deficiency (IgAd) were studied immunohistochemically to find markers of inflammation. Five of the 25 patients had coeliac disease (CD): they were on a gluten free diet and had normal jejunal morphology. Only two of 15 specimens from control subjects had CD25+ cells in the surface epithelium, while this was seen in 19 out of 20 specimens from IgAd patients (p+ cells was also noted in the lamina propria of IgAd patients. The median percentage of crypt cells in mitosis (Ki67+ cells) was higher in the specimens from IgAd patients (26%) than in those from controls (13%, p+ cells and with an increase in the mitotic rate in the crypts.

Original languageEnglish
Pages (from-to)519-523
Number of pages5
JournalGut
Volume37
Issue number4
Publication statusPublished - Oct 1995

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IgA Deficiency
Gluten-Free Diet
Celiac Disease
Mitosis
Mucous Membrane
Epithelium
Inflammation
Biopsy

Keywords

  • γδ T cell receptor
  • Coeliac disease
  • HLA class II antigens
  • IgA deficiency
  • Jejunal mucosa

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Klemola, T., Savilahti, E., Arató, A., Örmälä, T., Partanen, J., Eland, C., & Koskimies, S. (1995). Immimohistochemical findings in jejunal specimens from patients with IgA deficiency. Gut, 37(4), 519-523.

Immimohistochemical findings in jejunal specimens from patients with IgA deficiency. / Klemola, T.; Savilahti, E.; Arató, A.; Örmälä, T.; Partanen, J.; Eland, C.; Koskimies, S.

In: Gut, Vol. 37, No. 4, 10.1995, p. 519-523.

Research output: Contribution to journalArticle

Klemola, T, Savilahti, E, Arató, A, Örmälä, T, Partanen, J, Eland, C & Koskimies, S 1995, 'Immimohistochemical findings in jejunal specimens from patients with IgA deficiency', Gut, vol. 37, no. 4, pp. 519-523.
Klemola T, Savilahti E, Arató A, Örmälä T, Partanen J, Eland C et al. Immimohistochemical findings in jejunal specimens from patients with IgA deficiency. Gut. 1995 Oct;37(4):519-523.
Klemola, T. ; Savilahti, E. ; Arató, A. ; Örmälä, T. ; Partanen, J. ; Eland, C. ; Koskimies, S. / Immimohistochemical findings in jejunal specimens from patients with IgA deficiency. In: Gut. 1995 ; Vol. 37, No. 4. pp. 519-523.
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