Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect

György Domány, Tibor Gizur, Anikó Gere, K. Takács-Novák, György Farsang, G. Ferenczy, G. Tárkányi, Mária Demeter

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe2+-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 1998

Fingerprint

Quinazolines
Lipid Peroxidation
Lipids
Rats
Brain
Microsomes
NADP
Cyclic voltammetry
Antioxidants

Keywords

  • Antioxidant
  • Imidazo[1,2-c]quinazoline
  • Lipid peroxidation inhibitor
  • Lipophilicity

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect. / Domány, György; Gizur, Tibor; Gere, Anikó; Takács-Novák, K.; Farsang, György; Ferenczy, G.; Tárkányi, G.; Demeter, Mária.

In: European Journal of Medicinal Chemistry, Vol. 33, No. 3, 03.1998, p. 181-187.

Research output: Contribution to journalArticle

Domány, György ; Gizur, Tibor ; Gere, Anikó ; Takács-Novák, K. ; Farsang, György ; Ferenczy, G. ; Tárkányi, G. ; Demeter, Mária. / Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect. In: European Journal of Medicinal Chemistry. 1998 ; Vol. 33, No. 3. pp. 181-187.
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