Imaging of lung function using synchrotron radiation computed tomography

What's new?

Sam Bayat, Liisa Porra, Heikki Suhonen, Tibor Janosi, Satu Strengell, Walid Habre, F. Peták, Z. Hantos, Pekka Suortti, Anssi Sovijärvi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

There is a growing interest in imaging techniques as non-invasive means of quantitatively measuring regional lung structure and function. Abnormalities in lung ventilation due to alterations in airway function such as those observed in asthma and COPD are highly heterogeneous, and experimental methods to study this heterogeneity are crucial for better understanding of disease mechanisms and drug targeting strategies. In severe obstructive diseases requiring mechanical ventilation, the optimal ventilatory strategy to achieve recruitment of poorly ventilated lung zones remains a matter of considerable debate. We have used synchrotron radiation computed tomography (SRCT) for the in vivo study of regional lung ventilation and airway function. This imaging technique allows direct quantification of stable Xenon (Xe) gas used as an inhaled contrast agent using K-edge subtraction imaging. Dynamics of Xe wash-in can be used to calculate quantitative maps of regional specific lung ventilation. More recently, the development of Spiral-CT has allowed the acquisition of 3D images of the pulmonary bronchial tree and airspaces. This technique gives access to quantitative measurements of regional lung volume, ventilation, and mechanical properties. Examples of application in an experimental model of allergic asthma and in imaging lung recruitment as a function of mechanical ventilation parameters will be presented. The future orientations of this tecnique will be discussed.

Original languageEnglish
Pages (from-to)78-83
Number of pages6
JournalEuropean Journal of Radiology
Volume68
Issue number3 SUPPL.
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Synchrotrons
Tomography
Radiation
Lung
Artificial Respiration
Ventilation
Xenon
Asthma
Lung Volume Measurements
Spiral Computed Tomography
Drug Delivery Systems
Chronic Obstructive Pulmonary Disease
Contrast Media
Theoretical Models
Gases

Keywords

  • Bronchoconstriction
  • Computed tomography
  • Regional lung ventilation
  • Synchrotrons
  • Xenon

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Bayat, S., Porra, L., Suhonen, H., Janosi, T., Strengell, S., Habre, W., ... Sovijärvi, A. (2008). Imaging of lung function using synchrotron radiation computed tomography: What's new? European Journal of Radiology, 68(3 SUPPL.), 78-83. https://doi.org/10.1016/j.ejrad.2008.04.043

Imaging of lung function using synchrotron radiation computed tomography : What's new? / Bayat, Sam; Porra, Liisa; Suhonen, Heikki; Janosi, Tibor; Strengell, Satu; Habre, Walid; Peták, F.; Hantos, Z.; Suortti, Pekka; Sovijärvi, Anssi.

In: European Journal of Radiology, Vol. 68, No. 3 SUPPL., 12.2008, p. 78-83.

Research output: Contribution to journalArticle

Bayat, S, Porra, L, Suhonen, H, Janosi, T, Strengell, S, Habre, W, Peták, F, Hantos, Z, Suortti, P & Sovijärvi, A 2008, 'Imaging of lung function using synchrotron radiation computed tomography: What's new?', European Journal of Radiology, vol. 68, no. 3 SUPPL., pp. 78-83. https://doi.org/10.1016/j.ejrad.2008.04.043
Bayat, Sam ; Porra, Liisa ; Suhonen, Heikki ; Janosi, Tibor ; Strengell, Satu ; Habre, Walid ; Peták, F. ; Hantos, Z. ; Suortti, Pekka ; Sovijärvi, Anssi. / Imaging of lung function using synchrotron radiation computed tomography : What's new?. In: European Journal of Radiology. 2008 ; Vol. 68, No. 3 SUPPL. pp. 78-83.
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