Dopamintranszporter-vizsgálatok egyfoton-emissziós komputertomográfiával (SPECT) mozgászavarokkal járó kórképekben.

Translated title of the contribution: Imaging of dopamine transporter with Tc99m-Trodat-SPECT in movement disorders

Balázs Kanyó, Miklós Argyelán, György Dibó, Zsolt Szakonyi, László Vécsei, Ferenc Fülöp, Adrienn Láncz, Péter Forgács, László Pávics

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

99mTc-TRODAT-1 is a new, technetium based radiopharmaceutical that selectively binds to the dopamine transporters. The aim of the study was to evaluate the dopamine transporter status in movement disorders. METHODS: In eight healthy volunteers (age range 22-58 years), 28 patients with Parkinson's disease (age range 42-80 years), 10 patients with Parkinsonian syndrome (age range 51-79 years) and 13 patients with essential tremor (age range 43-71 years) were 99mTc-TRODAT-SPECT tests performed. The results were evaluated visually and semiquantitatively. RESULTS: The visual assessments were concordant with those of the semiquantitative in each case. The 99mTc-TRODAT uptake of the striatum was referenced to the cerebellum, the frontal and occipital cortex. The best deviation was found in aspect of the occipital cortex. The striatum/occipital ratio was the following: healthy volunteers: 2.12 +/- 0.27; Parkinson's disease: 1.52 +/- 0.27; Parkinsonian syndrome: 1.57 +/- 0.26; essential tremor: 2.06 +/- 0.69. The striatal dopamine transporter availability was significantly lower in subjects with Parkinson's disease or Parkinsonian syndrome compared to the control subjects. There was no difference between healthy volunteers and patients with essential tremor. Using discriminant analysis, the discriminant function had significantly different values in the group of Parkinson's disease than in Parkinsonian syndrome: f = -3.675 x caud/occipit + 6.293 x put/occipit -2.548. CONCLUSION: 99mTc-TRODAT-SPECT is able to visualise the presynaptic dopaminergic degeneration. This method itself can be useful in differential diagnosis in some type of movement disorders.

Translated title of the contributionImaging of dopamine transporter with Tc99m-Trodat-SPECT in movement disorders
Original languageHungarian
Pages (from-to)231-240
Number of pages10
JournalIdeggyógyászati szemle
Volume56
Issue number7-8
Publication statusPublished - Jul 20 2003

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Imaging of dopamine transporter with Tc99m-Trodat-SPECT in movement disorders'. Together they form a unique fingerprint.

  • Cite this