IL1B gene polymorphisms influence the course and severity of inflammatory bowel disease

Andrea Nemetz, M. Pilar Nosti-Escanilla, Tamás Molnár, Adorján Köpe, Ágota Kovács, János Fehér, Zsolt Tulassay, Ferenc Nagy, M. Asunción García-González, A. Salvador Peña

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

There is evidence of a disbalance in the inflammatory regulation of patients with inflammatory bowel diseases (IBD). Interleukin-1β plays an important role in the pro-inflammatory response. Our aim was to study the influence which IL1B gene polymorphisms may have on the severity and course of these diseases. Ninety-six patients with ulcerative colitis (UC), 98 patients with Crohn's disease (CD), and 132 ethnically matched healthy individuals (HC) were typed for the polymorphic sites in the promoter region (position -511) and in exon 5 (position +3953) of the IL1B gene, using polymerase chain reaction (PCR)based methods. In the CD group a significant association (P = 0.009) was found in this pair of genes. Homozygotes for allele 1 at position +3953 were more often present (69% vs 31%) in the subgroup of patients carrying at least one copy of allele 2 at position -511. This association was significant in patients with nonperforating disease (P = 0.002), but was not present in patients with perforating-fistulizing disease. The distribution of both allelic pairs in the non-fistulizing group proved to be significantly different from HC (P < 0.05), UC (P < 0.03), and the fistulizing group (P < 0.05). There was a similar association in non-operated patients (P = 0.024), whereas no such association was found in surgically treated patients. Among carriers of allele 2 at position -511, UC patients with more severe bleeding symptoms (P = 0.006) were less frequently found. These results suggest that IL1B gene polymorphisms participate in determining the course and severity of inflammatory bowel disease and contribute to explain the heterogeneity of these diseases.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalImmunogenetics
Volume49
Issue number6
DOIs
Publication statusPublished - May 22 1999

Keywords

  • Crohn's disease
  • Disease susceptibility
  • IL1B gene polymorphism
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Immunology
  • Genetics

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