IGR2096a_1 T and IGR2198a_1 C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn's disease in Hungarian patients

Lilla Lakner, Veronika Csöngei, Patrícia Sarlós, Luca Járomi, Enikö Sáfrány, Márta Varga, Péter Orosz, Lili Magyari, Judit Bene, Pál Miheller, Zsolt Tulassay, Béla Melegh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background and aims: We investigated the possible association of IBD with C1672T of SLC22A4 and G-207C of SLC22A5 alleles, and with the novel IGR2096a_1 (rs12521868) and IGR2198a_1 (rs11739135) susceptibility loci, all located on IBD5 locus of chromosome 5q31. Materials and methods: DNA of 217 Crohn's disease, 252 ulcerative colitis, and 290 control patients were analyzed by polymerase chain reaction/restriction fragment length polymorphism methods. Results: Neither the C1672T and G-207C alleles, nor the TC haplotype were found to be risk factors. By contrast, the minor allele frequencies of IGR2096a_1 T (47.2%) and IGR2198a_1 C (45.9%) were increased in Crohn's disease compared with the controls (38.2% and 37.7%, respectively; p < 0.05); multivariate regression analysis revealed a risk nature for Crohn's disease (OR = 1.748, 95% CI 1.186-2.574; p = 0.007 for T allele, OR = 1.646, 95% CI 1.119-2.423, p = 0.011 for C allele of IGRs). Conclusion: The data suggest a special haplotype arrangement of susceptibility genes at the IBD5 locus in Hungarians, which nation differs historically from the surrounding Caucasian ethnicities in its origin.

Original languageEnglish
Pages (from-to)503-507
Number of pages5
JournalInternational Journal of Colorectal Disease
Volume24
Issue number5
DOIs
Publication statusPublished - Feb 13 2009

Keywords

  • Crohn's disease
  • Hungarian
  • IGR
  • SLC22A4
  • SLC22A5

ASJC Scopus subject areas

  • Gastroenterology

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