IgE class immune complexes in Felty's syndrome: Characterisation of antibody activities in isolated complexes

K. Meretey, A. Falus, U. Bohm

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

By means of a double polyethylene glycol (PEG) precipitation and PRIST technique IgE was detected in 3% PEG precipitates and in the immune complex enriched fractions purified by solid-phase C1q adsorption from sera of 11 of 20 patients with Felty's syndrome. No correlation was found between the occurrence of complexes IgE and total protein content of the immune complex enriched material. IgE rheumatoid factor and anti-IgE antibody activity were detected in some of the immune complex fractions. Serum levels of complement C3, C4, and factor B were low in IgE immune complex positive cases. Only 4 of 20 patients with articular rheumatoid arthritis had IgE-containing immune complexes.

Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalAnnals of the Rheumatic Diseases
Volume43
Issue number2
Publication statusPublished - 1984

Fingerprint

Felty Syndrome
Antigen-Antibody Complex
Immunoglobulin E
Antibodies
Complement C4
Complement C3
Complement Factor B
Rheumatoid Factor
Serum
Adsorption
Precipitates
Rheumatoid Arthritis
Joints
Proteins

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

IgE class immune complexes in Felty's syndrome : Characterisation of antibody activities in isolated complexes. / Meretey, K.; Falus, A.; Bohm, U.

In: Annals of the Rheumatic Diseases, Vol. 43, No. 2, 1984, p. 246-250.

Research output: Contribution to journalArticle

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