Identified Cellular Correlates of Neocortical Ripple and High-Gamma Oscillations during Spindles of Natural Sleep

Robert G. Averkin, Viktor Szemenyei, Sándor Bordé, Gábor Tamás

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Ultra-high-frequency network events in the hippocampus are instrumental in a dialogue with the neocortex during memory formation, but the existence of transient ∼200 Hz network events in the neocortex is not clear. Our recordings from neocortical layer II/III of freely behaving rats revealed field potential events at ripple and high-gamma frequencies repeatedly occurring at troughs of spindle oscillations during sleep. Juxtacellular recordings identified subpopulations of fast-spiking, parvalbumin-containing basket cells with epochs of firing at ripple (∼200 Hz) and high-gamma (∼120 Hz) frequencies detected during spindles and centered with millisecond precision at the trough of spindle waves in phase with field potential events but phase shifted relative to pyramidal cell firing. The results suggest that basket cell subpopulations are involved in spindle-nested, high-frequency network events that hypothetically provide repeatedly occurring neocortical temporal reference states potentially involved in mnemonic processes.

Original languageEnglish
Pages (from-to)916-928
Number of pages13
JournalNeuron
Volume92
Issue number4
DOIs
Publication statusPublished - Nov 23 2016

ASJC Scopus subject areas

  • Neuroscience(all)

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