Identification of subsets of patients with Graves' disease by cluster analysis

V. Stenszky, C. Balázs, L. Kozma, S. Rochlitz, J. C. Bear, N. R. Farid

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We have applied cluster analysis methods to forty-nine laboratory and clinical characteristics (including 26 HLA-A, B antigens) observed in 196 Graves' disease patients. Three subgroups could be identified: group I (seventy-nine patients) had small goitres, low indices of autoimmunity and a tendency to remission with medical treatment; group IIa (twenty-nine patients) had clinical and laboratory features of 'Hashitoxicosis'; Group IIb (eighty-four patients) had a high incidence of ophthalmopathy, familial aggregation, marked evidence of autoaggression and a tendency to relapsing hyperthyroidism. The prevalence of HLA-B8 was 8.9% in group I, 20.7% in group IIa and 86.9% in group IIb. This study demonstrates that Graves' disease can be subdivided using cluster analysis into clinically relevant subgroups which are further distinguished by their correlation with HLA-B8. Possible immunological bases for these observed patterns are discussed.

Original languageEnglish
Pages (from-to)335-345
Number of pages11
JournalClinical Endocrinology
Volume18
Issue number4
Publication statusPublished - 1983

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Graves Disease
Cluster Analysis
HLA-B8 Antigen
HLA-A Antigens
HLA-B Antigens
Goiter
Hyperthyroidism
Autoimmunity
Incidence
Therapeutics

ASJC Scopus subject areas

  • Endocrinology

Cite this

Stenszky, V., Balázs, C., Kozma, L., Rochlitz, S., Bear, J. C., & Farid, N. R. (1983). Identification of subsets of patients with Graves' disease by cluster analysis. Clinical Endocrinology, 18(4), 335-345.

Identification of subsets of patients with Graves' disease by cluster analysis. / Stenszky, V.; Balázs, C.; Kozma, L.; Rochlitz, S.; Bear, J. C.; Farid, N. R.

In: Clinical Endocrinology, Vol. 18, No. 4, 1983, p. 335-345.

Research output: Contribution to journalArticle

Stenszky, V, Balázs, C, Kozma, L, Rochlitz, S, Bear, JC & Farid, NR 1983, 'Identification of subsets of patients with Graves' disease by cluster analysis', Clinical Endocrinology, vol. 18, no. 4, pp. 335-345.
Stenszky V, Balázs C, Kozma L, Rochlitz S, Bear JC, Farid NR. Identification of subsets of patients with Graves' disease by cluster analysis. Clinical Endocrinology. 1983;18(4):335-345.
Stenszky, V. ; Balázs, C. ; Kozma, L. ; Rochlitz, S. ; Bear, J. C. ; Farid, N. R. / Identification of subsets of patients with Graves' disease by cluster analysis. In: Clinical Endocrinology. 1983 ; Vol. 18, No. 4. pp. 335-345.
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