Identification of Schizosaccharomyces pombe genes that encode putative homologues of Saccharomyces cerevisiae mediator complex subunits

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Abstract

The mediator complexes transduce regulatory information from upstream regulatory elements to the transcription machinery in organisms ranging from yeasts to humans. By a genome-wide search we identified 14 ORFs and genes in the genome of the fission yeast Schizosaccharomyces pombe that encode putative homologues of Saccharomyces cerevisiae mediator subunits. The Sch. pombe proteins are smaller and appear to form a mediator of lower complexity, which is consistent with the hypothesized ancient origin of fission yeasts.

Original languageEnglish
Pages (from-to)519-531
Number of pages13
JournalActa Microbiologica et Immunologica Hungarica
Volume48
Issue number3-4
DOIs
Publication statusPublished - 2001

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Mediator Complex
Schizosaccharomyces
Saccharomyces cerevisiae
Schizosaccharomyces pombe Proteins
Genome
Genes
Open Reading Frames
Yeasts

Keywords

  • BLAST
  • Fission yeast
  • Mediator
  • Phylogenesis
  • Transcription

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

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AB - The mediator complexes transduce regulatory information from upstream regulatory elements to the transcription machinery in organisms ranging from yeasts to humans. By a genome-wide search we identified 14 ORFs and genes in the genome of the fission yeast Schizosaccharomyces pombe that encode putative homologues of Saccharomyces cerevisiae mediator subunits. The Sch. pombe proteins are smaller and appear to form a mediator of lower complexity, which is consistent with the hypothesized ancient origin of fission yeasts.

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KW - Phylogenesis

KW - Transcription

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