Identification of protein substrates for transglutaminase in Caenorhabditis elegans

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13 Citations (Scopus)


Transglutaminase-dependent cross-linking of proteins leads to protein polymerisation that confers stability as well as resistance to mechanical disruption and chemical attack. Various transglutaminases have been implicated in a wide range of biological phenomena occurring in both extracellular and intracellular compartments, but further clarification of the physiological role of these enzymes requires identification of possible substrate molecules. Here we report the detection, purification, and identification of two proteins, enolase and ATP synthase α subunit as glutamine donor protein substrates for the transglutaminase of the nematode Caenorhabditis elegans.

Original languageEnglish
Pages (from-to)964-968
Number of pages5
JournalBiochemical and biophysical research communications
Issue number4
Publication statusPublished - Jan 1 2001


  • Caenorhabditis elegans
  • Enolase
  • Mitochondrial ATP synthase
  • Substrate
  • Transglutaminase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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