Identification of important compounds isolated from natural sources that have activity against multidrug-resistant cancer cell lines: Effects on proliferation, apoptotic mechanism and the efflux pump responsible for multi-resistance phenotype

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The focus of this mini-review is to identify non-toxic compounds isolated from natural sources (plants) that exhibit specific activity against efflux pumps of specific multidrug-resistant (MDR) cancer cell lines, inhibit proliferation of the MDR cancer cell lines and inhibit the activity of overexpressed efflux pumps of the MDR cancer cell line.

Original languageEnglish
Pages (from-to)5665-5672
Number of pages8
JournalAnticancer research
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 2016

Keywords

  • Induction of apoptosis
  • Inhibition of P-glycoprotein (ABCB1)
  • Multidrug-resistant cancer cell lines
  • Non-toxic compounds isolated from natural sources (plants)
  • Reversal of multidrug resistance
  • Review

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Identification of important compounds isolated from natural sources that have activity against multidrug-resistant cancer cell lines: Effects on proliferation, apoptotic mechanism and the efflux pump responsible for multi-resistance phenotype'. Together they form a unique fingerprint.

  • Cite this