Identification of a porcine calicivirus related genetically to human sapoviruses

V. Martella, E. Lorusso, K. Banyai, N. Decaro, M. Corrente, G. Elia, A. Cavalli, A. Radogna, V. Costantini, L. J. Saif, A. Lavazza, L. Di Trani, C. Buonavoglia

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Abstract

Whether animals may act as reservoirs for human caliciviruses is unclear. By sequence analysis of a short fragment of the RNA-dependent RNA polymerase (RdRp) region, porcine sapovirus (SaV) strains that genetically resemble human SaVs have been detected in piglets, but more-informative sequences (capsid gene) were not available for a precise characterization. In this study, the 3′ terminus (the 3′ end of open reading frame 1 [ORF1], including the polymerase complex and the complete capsid; ORF2; and the 3′ untranslated region) of one such human SaV-like strain, 43/06-18p3/2006/It, was determined, revealing that these viruses are more related genetically to human (47.4 to 54.9% amino acid identity) than to animal (35.2 to 44.7% amino acid identity) SaVs in the capsid gene. In addition, the recombination-prone RdRp-capsid junction region was highly conserved with those of human SaVs of genogroup GI. The presence of porcine viruses similar to human SaVs is a significant finding because of the potential for zoonotic infections or generation of porcine/human recombinants.

Original languageEnglish
Pages (from-to)1907-1913
Number of pages7
JournalJournal of Clinical Microbiology
Volume46
Issue number6
DOIs
Publication statusPublished - Jun 2008

ASJC Scopus subject areas

  • Microbiology (medical)

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    Martella, V., Lorusso, E., Banyai, K., Decaro, N., Corrente, M., Elia, G., Cavalli, A., Radogna, A., Costantini, V., Saif, L. J., Lavazza, A., Di Trani, L., & Buonavoglia, C. (2008). Identification of a porcine calicivirus related genetically to human sapoviruses. Journal of Clinical Microbiology, 46(6), 1907-1913. https://doi.org/10.1128/JCM.00341-08