Identification of a multi-reassortant G12P[9] rotavirus with novel VP1, VP2, VP3 and NSP2 genotypes in a child with acute gastroenteritis

Simona De Grazia, Giovanni M. Giammanco, Renáta Dóró, Floriana Bonura, Szilvia Marton, Antonio Cascio, Vito Martella, K. Bányai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The G12 rotavirus genotype is globally emerging to cause severe gastroenteritis in children. Common G12 rotaviruses have either a Wa-like or DS-1-like genome constellation, while some G12 strains may have unusual genome composition. In this study, we determined the full-genome sequence of a G12P[9] strain (ME848/12) detected in a child hospitalized with acute gastroenteritis in Italy in 2012. Strain ME848/12 showed a complex genetic constellation (G12-P[9]-I17-R12-C12-M11-A12-N12-T7-E6-H2), likely derived from multiple reassortment events, with the VP1, VP2, VP3 and NSP2 genes being established as novel genotypes R12, C12, M11 and N12, respectively. Gathering sequence data on human and animal rotaviruses is important to trace the complex evolutionary history of atypical RVAs.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalInfection, Genetics and Evolution
Volume35
DOIs
Publication statusPublished - Oct 1 2015

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gastroenteritis
Rotavirus
Gastroenteritis
genotype
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Genotype
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Hospitalized Child
compound A 12
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history
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animal
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animals
genes

Keywords

  • Full genome sequencing
  • G12P[9]
  • Genotyping
  • Human rotavirus
  • Interspecies transmission
  • Reassortment

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Infectious Diseases
  • Microbiology (medical)

Cite this

Identification of a multi-reassortant G12P[9] rotavirus with novel VP1, VP2, VP3 and NSP2 genotypes in a child with acute gastroenteritis. / De Grazia, Simona; Giammanco, Giovanni M.; Dóró, Renáta; Bonura, Floriana; Marton, Szilvia; Cascio, Antonio; Martella, Vito; Bányai, K.

In: Infection, Genetics and Evolution, Vol. 35, 01.10.2015, p. 34-37.

Research output: Contribution to journalArticle

De Grazia, Simona ; Giammanco, Giovanni M. ; Dóró, Renáta ; Bonura, Floriana ; Marton, Szilvia ; Cascio, Antonio ; Martella, Vito ; Bányai, K. / Identification of a multi-reassortant G12P[9] rotavirus with novel VP1, VP2, VP3 and NSP2 genotypes in a child with acute gastroenteritis. In: Infection, Genetics and Evolution. 2015 ; Vol. 35. pp. 34-37.
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