A "3q21q26-szindróma" azonosítása sokpontos interfázis-FISH vizsgálattal gyermekkori myeloid leukaemiában

Translated title of the contribution: Identification of 3q21q26 syndrome by "multipoint" interphase FISH analyses in childhood myeloid leukemia

Haltrich Irén, Maria Kost-Alimova, Kovács Gábor, Kriván Gergely, Dobos Matild, Stefan Imreh, G. Fekete

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cytogenetic syndrome involving bands 3q21 and 3q26, known as "3q21q26 syndrome" has been observed in adult patients with acute myelogenous leukemia (0,5-2%), chronic myelogenous leukemia in blast crisis (20%), myelodysplastic syndromes and myeloproliferative disorders. In the present study bone marrow samples from two boys (12 and 16 years), diagnosed with CML and AML respectively, were investigated using conventional cytogenetic methods, interphase "multipoint" fluorescence in situ hybridization (FISH), dual color-FISH and multiplex FISH. The "multipoint" FISH analysis identified in de novo childhood AML case an inv(3)(q21q26) and a complex 3q rearrangement including inversion and duplication in the CML case. The "3q21q26 syndrome" is associated with normal or elevated platelet counts with marked abnormalities of megakaryocytopoiesis, involvement of multiple hematopoietic lineages. The affected patients were resistant to conventional chemotherapy and had a short survival. This syndrome is very rare in de novo childhood AML, and simultaneous presence of 3q inversion and duplication, to our knowledge, has not yet been identified in hematological malignancies. The results of our study underline the importance of classical and modern cytogenetic analysis in the diagnosis of hematological malignancies, because in the majority of cases they can provide additional diagnostic information for the clinicians in deciding the best therapeutic approach, precise classification and prognosis of the disease.

Original languageHungarian
Pages (from-to)141-147
Number of pages7
JournalMagyar Onkologia
Volume49
Issue number2
Publication statusPublished - 2005

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Myeloid Leukemia
Interphase
Fluorescence In Situ Hybridization
Hematologic Neoplasms
Cytogenetics
Thrombopoiesis
Blast Crisis
Myeloproliferative Disorders
Cytogenetic Analysis
Myelodysplastic Syndromes
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Platelet Count
Acute Myeloid Leukemia
Color
Bone Marrow
Drug Therapy
Survival
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Irén, H., Kost-Alimova, M., Gábor, K., Gergely, K., Matild, D., Imreh, S., & Fekete, G. (2005). A "3q21q26-szindróma" azonosítása sokpontos interfázis-FISH vizsgálattal gyermekkori myeloid leukaemiában. Magyar Onkologia, 49(2), 141-147.

A "3q21q26-szindróma" azonosítása sokpontos interfázis-FISH vizsgálattal gyermekkori myeloid leukaemiában. / Irén, Haltrich; Kost-Alimova, Maria; Gábor, Kovács; Gergely, Kriván; Matild, Dobos; Imreh, Stefan; Fekete, G.

In: Magyar Onkologia, Vol. 49, No. 2, 2005, p. 141-147.

Research output: Contribution to journalArticle

Irén, H, Kost-Alimova, M, Gábor, K, Gergely, K, Matild, D, Imreh, S & Fekete, G 2005, 'A "3q21q26-szindróma" azonosítása sokpontos interfázis-FISH vizsgálattal gyermekkori myeloid leukaemiában', Magyar Onkologia, vol. 49, no. 2, pp. 141-147.
Irén H, Kost-Alimova M, Gábor K, Gergely K, Matild D, Imreh S et al. A "3q21q26-szindróma" azonosítása sokpontos interfázis-FISH vizsgálattal gyermekkori myeloid leukaemiában. Magyar Onkologia. 2005;49(2):141-147.
Irén, Haltrich ; Kost-Alimova, Maria ; Gábor, Kovács ; Gergely, Kriván ; Matild, Dobos ; Imreh, Stefan ; Fekete, G. / A "3q21q26-szindróma" azonosítása sokpontos interfázis-FISH vizsgálattal gyermekkori myeloid leukaemiában. In: Magyar Onkologia. 2005 ; Vol. 49, No. 2. pp. 141-147.
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abstract = "Cytogenetic syndrome involving bands 3q21 and 3q26, known as {"}3q21q26 syndrome{"} has been observed in adult patients with acute myelogenous leukemia (0,5-2{\%}), chronic myelogenous leukemia in blast crisis (20{\%}), myelodysplastic syndromes and myeloproliferative disorders. In the present study bone marrow samples from two boys (12 and 16 years), diagnosed with CML and AML respectively, were investigated using conventional cytogenetic methods, interphase {"}multipoint{"} fluorescence in situ hybridization (FISH), dual color-FISH and multiplex FISH. The {"}multipoint{"} FISH analysis identified in de novo childhood AML case an inv(3)(q21q26) and a complex 3q rearrangement including inversion and duplication in the CML case. The {"}3q21q26 syndrome{"} is associated with normal or elevated platelet counts with marked abnormalities of megakaryocytopoiesis, involvement of multiple hematopoietic lineages. The affected patients were resistant to conventional chemotherapy and had a short survival. This syndrome is very rare in de novo childhood AML, and simultaneous presence of 3q inversion and duplication, to our knowledge, has not yet been identified in hematological malignancies. The results of our study underline the importance of classical and modern cytogenetic analysis in the diagnosis of hematological malignancies, because in the majority of cases they can provide additional diagnostic information for the clinicians in deciding the best therapeutic approach, precise classification and prognosis of the disease.",
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AU - Kost-Alimova, Maria

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AU - Gergely, Kriván

AU - Matild, Dobos

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AU - Fekete, G.

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