Ideal cardiovascular health and inflammation in European adolescents: The HELENA study

E. M. González-Gil, J. Santabárbara, J. R. Ruiz, S. Bel-Serrat, I. Huybrechts, R. Pedrero-Chamizo, A. de la O, F. Gottrand, A. Kafatos, K. Widhalm, Y. Manios, D. Molnár, S. De Henauw, M. Plada, M. Ferrari, G. Palacios Le Blé, A. Siani, M. González-Gross, S. Gómez-Martínez, A. MarcosL. A. Moreno Aznar, L. A. Moreno, F. Gottrand, S. De Henauw, M. González-Gross, C. Gilbert, A. Kafatos, C. Libersa, S. Castelló, M. Kersting, M. Sjöstrom, D. Molnár, J. Dallongeville, G. Hall, L. Maes, L. Scalfi, P. Meléndez, J. Fleta, J. A. Casajús, G. Rodríguez, C. Tomás, M. I. Mesana, G. Vicente-Rodríguez, A. Villarroya, C. M. Gil, I. Ara, J. F. Alvira, G. Bueno, A. Lázaro, O. Bueno, J. F. León, J. M. Garagorri, M. Bueno, I. Labayen, I. Iglesia, S. Bel Serrat, L. A. Gracia Marco, T. Mouratidou, A. Santaliestra-Pasías, E. M. González-Gil, P. De Miguel-Etayo, C. Julián Almárcegui, M. Miguel-Berges, I. Iguacel, A. Marcos, J. Wärnberg, E. Nova, S. Gómez, L. E. Díaz, J. Romeo, A. Veses, B. Zapatera, T. Pozo, D. Martínez, L. Beghin, F. Gottrand, C. Iliescu, J. Von Berlepsch, W. Sichert-Hellert, E. Koeppen, D. Molnar, E. Erhardt, K. Csernus, K. Török, S. Bokor, Angster, E. Nagy, O. Kovács, J. Répasi, C. Codrington, M. Plada, A. Papadaki, K. Sarri, A. Viskadourou, C. Hatzis, M. Kiriakakis, G. Tsibinos, C. Vardavas, M. Sbokos, E. Protoyeraki, M. Fasoulaki, P. Stehle, K. Pietrzik, C. Breidenassel, A. Spinneker, J. Al-Tahan, M. Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, M. J. Castillo, Gutiérrez, F. B. Ortega, J. R. Ruiz, E. G. Artero, V. España, D. Jiménez-Pavón, P. Chillón, C. Sánchez-Muñoz, M. Cuenca, D. Arcella, E. Azzini, E. Barrison, N. Bevilacqua, P. Buonocore, G. Catasta, L. Censi, D. Ciarapica, P. D'Acapito, M. Ferrari, M. Galfo, C. Le Donne, C. Leclercq, G. Maiani, B. Mauro, L. Mistura, A. Pasquali, R. Piccinelli, A. Polito, R. Roccaldo, R. Spada, S. Sette, M. Zaccaria, P. Vitaglione, C. Montagnese, I. De Bourdeaudhuij, T. De Vriendt, C. Matthys, C. Vereecken, M. de Maeyer, C. Ottevaere, I. Huybrechts, K. Widhalm, K. Phillipp, S. Dietrich, Y. Manios, E. Grammatikaki, Z. Bouloubasi, T. L. Cook, S. Eleutheriou, O. Consta, G. Moschonis, I. Katsaroli, G. Kraniou, S. Papoutsou, D. Keke, I. Petraki, E. Bellou, S. Tanagra, K. Kallianoti, D. Argyropoulou, S. Tsikrika, C. Karaiskos, A. Meirhaeghe, F. B. Ortega, M. Hagströmer, A. H. Wennlöf, L. Hallström, E. Patterson, L. Kwak, N. Rizzo, J. Sánchez-Molero, E. Picó, M. Navarro, B. Viadel, J. E. Carreres, G. Merino, R. Sanjuán, M. Lorente, M. J. Sánchez, S. Thomas, E. Allchurch, P. Burgess, A. Astrom, A. Sverkén, A. Broberg, A. Masson, C. Lehoux, P. Brabant, P. Pate, L. Fontaine, A. Sebok, T. Kuti, A. Hegyi, C. Maldonado, A. Llorente, E. García, H. von Fircks, M. L. Hallberg, M. Messerer, M. Larsson, H. Fredriksson, V. Adamsson, I. Börjesson, L. Fernández, L. Smillie, J. Wills, R. Pedrero-Chamizo, A. Meléndez, J. Valtueña, U. Albers, P. J. Benito, J. J. Gómez Lorente, D. Cañada, A. Urzanqui, R. M. Torres, P. Navarro

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents. Methods and results As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1% in girls. Conclusion Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.

Original languageEnglish
Pages (from-to)447-455
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume27
Issue number5
DOIs
Publication statusPublished - May 1 2017

Fingerprint

Inflammation
Health
C-Reactive Protein
Logistic Models
Healthy Lifestyle
Complement C4
Complement C3
Health Behavior
Atherosclerotic Plaques
Leptin
Leukocyte Count
Linear Models
Atherosclerosis
Cross-Sectional Studies
Biomarkers

Keywords

  • Cardiovascular health
  • European adolescents
  • Inflammation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

González-Gil, E. M., Santabárbara, J., Ruiz, J. R., Bel-Serrat, S., Huybrechts, I., Pedrero-Chamizo, R., ... Navarro, P. (2017). Ideal cardiovascular health and inflammation in European adolescents: The HELENA study. Nutrition, Metabolism and Cardiovascular Diseases, 27(5), 447-455. https://doi.org/10.1016/j.numecd.2016.12.003

Ideal cardiovascular health and inflammation in European adolescents : The HELENA study. / González-Gil, E. M.; Santabárbara, J.; Ruiz, J. R.; Bel-Serrat, S.; Huybrechts, I.; Pedrero-Chamizo, R.; de la O, A.; Gottrand, F.; Kafatos, A.; Widhalm, K.; Manios, Y.; Molnár, D.; De Henauw, S.; Plada, M.; Ferrari, M.; Palacios Le Blé, G.; Siani, A.; González-Gross, M.; Gómez-Martínez, S.; Marcos, A.; Moreno Aznar, L. A.; Moreno, L. A.; Gottrand, F.; De Henauw, S.; González-Gross, M.; Gilbert, C.; Kafatos, A.; Libersa, C.; Castelló, S.; Kersting, M.; Sjöstrom, M.; Molnár, D.; Dallongeville, J.; Hall, G.; Maes, L.; Scalfi, L.; Meléndez, P.; Fleta, J.; Casajús, J. A.; Rodríguez, G.; Tomás, C.; Mesana, M. I.; Vicente-Rodríguez, G.; Villarroya, A.; Gil, C. M.; Ara, I.; Alvira, J. F.; Bueno, G.; Lázaro, A.; Bueno, O.; León, J. F.; Garagorri, J. M.; Bueno, M.; Labayen, I.; Iglesia, I.; Bel Serrat, S.; Gracia Marco, L. A.; Mouratidou, T.; Santaliestra-Pasías, A.; González-Gil, E. M.; De Miguel-Etayo, P.; Julián Almárcegui, C.; Miguel-Berges, M.; Iguacel, I.; Marcos, A.; Wärnberg, J.; Nova, E.; Gómez, S.; Díaz, L. E.; Romeo, J.; Veses, A.; Zapatera, B.; Pozo, T.; Martínez, D.; Beghin, L.; Gottrand, F.; Iliescu, C.; Von Berlepsch, J.; Sichert-Hellert, W.; Koeppen, E.; Molnar, D.; Erhardt, E.; Csernus, K.; Török, K.; Bokor, S.; Angster; Nagy, E.; Kovács, O.; Répasi, J.; Codrington, C.; Plada, M.; Papadaki, A.; Sarri, K.; Viskadourou, A.; Hatzis, C.; Kiriakakis, M.; Tsibinos, G.; Vardavas, C.; Sbokos, M.; Protoyeraki, E.; Fasoulaki, M.; Stehle, P.; Pietrzik, K.; Breidenassel, C.; Spinneker, A.; Al-Tahan, J.; Segoviano, M.; Berchtold, A.; Bierschbach, C.; Blatzheim, E.; Schuch, A.; Pickert, P.; Castillo, M. J.; Gutiérrez; Ortega, F. B.; Ruiz, J. R.; Artero, E. G.; España, V.; Jiménez-Pavón, D.; Chillón, P.; Sánchez-Muñoz, C.; Cuenca, M.; Arcella, D.; Azzini, E.; Barrison, E.; Bevilacqua, N.; Buonocore, P.; Catasta, G.; Censi, L.; Ciarapica, D.; D'Acapito, P.; Ferrari, M.; Galfo, M.; Le Donne, C.; Leclercq, C.; Maiani, G.; Mauro, B.; Mistura, L.; Pasquali, A.; Piccinelli, R.; Polito, A.; Roccaldo, R.; Spada, R.; Sette, S.; Zaccaria, M.; Vitaglione, P.; Montagnese, C.; De Bourdeaudhuij, I.; De Vriendt, T.; Matthys, C.; Vereecken, C.; de Maeyer, M.; Ottevaere, C.; Huybrechts, I.; Widhalm, K.; Phillipp, K.; Dietrich, S.; Manios, Y.; Grammatikaki, E.; Bouloubasi, Z.; Cook, T. L.; Eleutheriou, S.; Consta, O.; Moschonis, G.; Katsaroli, I.; Kraniou, G.; Papoutsou, S.; Keke, D.; Petraki, I.; Bellou, E.; Tanagra, S.; Kallianoti, K.; Argyropoulou, D.; Tsikrika, S.; Karaiskos, C.; Meirhaeghe, A.; Ortega, F. B.; Hagströmer, M.; Wennlöf, A. H.; Hallström, L.; Patterson, E.; Kwak, L.; Rizzo, N.; Sánchez-Molero, J.; Picó, E.; Navarro, M.; Viadel, B.; Carreres, J. E.; Merino, G.; Sanjuán, R.; Lorente, M.; Sánchez, M. J.; Thomas, S.; Allchurch, E.; Burgess, P.; Astrom, A.; Sverkén, A.; Broberg, A.; Masson, A.; Lehoux, C.; Brabant, P.; Pate, P.; Fontaine, L.; Sebok, A.; Kuti, T.; Hegyi, A.; Maldonado, C.; Llorente, A.; García, E.; von Fircks, H.; Hallberg, M. L.; Messerer, M.; Larsson, M.; Fredriksson, H.; Adamsson, V.; Börjesson, I.; Fernández, L.; Smillie, L.; Wills, J.; Pedrero-Chamizo, R.; Meléndez, A.; Valtueña, J.; Albers, U.; Benito, P. J.; Gómez Lorente, J. J.; Cañada, D.; Urzanqui, A.; Torres, R. M.; Navarro, P.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 27, No. 5, 01.05.2017, p. 447-455.

Research output: Contribution to journalArticle

González-Gil, EM, Santabárbara, J, Ruiz, JR, Bel-Serrat, S, Huybrechts, I, Pedrero-Chamizo, R, de la O, A, Gottrand, F, Kafatos, A, Widhalm, K, Manios, Y, Molnár, D, De Henauw, S, Plada, M, Ferrari, M, Palacios Le Blé, G, Siani, A, González-Gross, M, Gómez-Martínez, S, Marcos, A, Moreno Aznar, LA, Moreno, LA, Gottrand, F, De Henauw, S, González-Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Castelló, S, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, JA, Rodríguez, G, Tomás, C, Mesana, MI, Vicente-Rodríguez, G, Villarroya, A, Gil, CM, Ara, I, Alvira, JF, Bueno, G, Lázaro, A, Bueno, O, León, JF, Garagorri, JM, Bueno, M, Labayen, I, Iglesia, I, Bel Serrat, S, Gracia Marco, LA, Mouratidou, T, Santaliestra-Pasías, A, González-Gil, EM, De Miguel-Etayo, P, Julián Almárcegui, C, Miguel-Berges, M, Iguacel, I, Marcos, A, Wärnberg, J, Nova, E, Gómez, S, Díaz, LE, Romeo, J, Veses, A, Zapatera, B, Pozo, T, Martínez, D, Beghin, L, Gottrand, F, Iliescu, C, Von Berlepsch, J, Sichert-Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al-Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, MJ, Gutiérrez, Ortega, FB, Ruiz, JR, Artero, EG, España, V, Jiménez-Pavón, D, Chillón, P, Sánchez-Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Roccaldo, R, Spada, R, Sette, S, Zaccaria, M, Vitaglione, P, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrechts, I, Widhalm, K, Phillipp, K, Dietrich, S, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, TL, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Ortega, FB, Hagströmer, M, Wennlöf, AH, Hallström, L, Patterson, E, Kwak, L, Rizzo, N, Sánchez-Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, JE, Merino, G, Sanjuán, R, Lorente, M, Sánchez, MJ, Thomas, S, Allchurch, E, Burgess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, ML, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Pedrero-Chamizo, R, Meléndez, A, Valtueña, J, Albers, U, Benito, PJ, Gómez Lorente, JJ, Cañada, D, Urzanqui, A, Torres, RM & Navarro, P 2017, 'Ideal cardiovascular health and inflammation in European adolescents: The HELENA study', Nutrition, Metabolism and Cardiovascular Diseases, vol. 27, no. 5, pp. 447-455. https://doi.org/10.1016/j.numecd.2016.12.003
González-Gil EM, Santabárbara J, Ruiz JR, Bel-Serrat S, Huybrechts I, Pedrero-Chamizo R et al. Ideal cardiovascular health and inflammation in European adolescents: The HELENA study. Nutrition, Metabolism and Cardiovascular Diseases. 2017 May 1;27(5):447-455. https://doi.org/10.1016/j.numecd.2016.12.003
González-Gil, E. M. ; Santabárbara, J. ; Ruiz, J. R. ; Bel-Serrat, S. ; Huybrechts, I. ; Pedrero-Chamizo, R. ; de la O, A. ; Gottrand, F. ; Kafatos, A. ; Widhalm, K. ; Manios, Y. ; Molnár, D. ; De Henauw, S. ; Plada, M. ; Ferrari, M. ; Palacios Le Blé, G. ; Siani, A. ; González-Gross, M. ; Gómez-Martínez, S. ; Marcos, A. ; Moreno Aznar, L. A. ; Moreno, L. A. ; Gottrand, F. ; De Henauw, S. ; González-Gross, M. ; Gilbert, C. ; Kafatos, A. ; Libersa, C. ; Castelló, S. ; Kersting, M. ; Sjöstrom, M. ; Molnár, D. ; Dallongeville, J. ; Hall, G. ; Maes, L. ; Scalfi, L. ; Meléndez, P. ; Fleta, J. ; Casajús, J. A. ; Rodríguez, G. ; Tomás, C. ; Mesana, M. I. ; Vicente-Rodríguez, G. ; Villarroya, A. ; Gil, C. M. ; Ara, I. ; Alvira, J. F. ; Bueno, G. ; Lázaro, A. ; Bueno, O. ; León, J. F. ; Garagorri, J. M. ; Bueno, M. ; Labayen, I. ; Iglesia, I. ; Bel Serrat, S. ; Gracia Marco, L. A. ; Mouratidou, T. ; Santaliestra-Pasías, A. ; González-Gil, E. M. ; De Miguel-Etayo, P. ; Julián Almárcegui, C. ; Miguel-Berges, M. ; Iguacel, I. ; Marcos, A. ; Wärnberg, J. ; Nova, E. ; Gómez, S. ; Díaz, L. E. ; Romeo, J. ; Veses, A. ; Zapatera, B. ; Pozo, T. ; Martínez, D. ; Beghin, L. ; Gottrand, F. ; Iliescu, C. ; Von Berlepsch, J. ; Sichert-Hellert, W. ; Koeppen, E. ; Molnar, D. ; Erhardt, E. ; Csernus, K. ; Török, K. ; Bokor, S. ; Angster ; Nagy, E. ; Kovács, O. ; Répasi, J. ; Codrington, C. ; Plada, M. ; Papadaki, A. ; Sarri, K. ; Viskadourou, A. ; Hatzis, C. ; Kiriakakis, M. ; Tsibinos, G. ; Vardavas, C. ; Sbokos, M. ; Protoyeraki, E. ; Fasoulaki, M. ; Stehle, P. ; Pietrzik, K. ; Breidenassel, C. ; Spinneker, A. ; Al-Tahan, J. ; Segoviano, M. ; Berchtold, A. ; Bierschbach, C. ; Blatzheim, E. ; Schuch, A. ; Pickert, P. ; Castillo, M. J. ; Gutiérrez ; Ortega, F. B. ; Ruiz, J. R. ; Artero, E. G. ; España, V. ; Jiménez-Pavón, D. ; Chillón, P. ; Sánchez-Muñoz, C. ; Cuenca, M. ; Arcella, D. ; Azzini, E. ; Barrison, E. ; Bevilacqua, N. ; Buonocore, P. ; Catasta, G. ; Censi, L. ; Ciarapica, D. ; D'Acapito, P. ; Ferrari, M. ; Galfo, M. ; Le Donne, C. ; Leclercq, C. ; Maiani, G. ; Mauro, B. ; Mistura, L. ; Pasquali, A. ; Piccinelli, R. ; Polito, A. ; Roccaldo, R. ; Spada, R. ; Sette, S. ; Zaccaria, M. ; Vitaglione, P. ; Montagnese, C. ; De Bourdeaudhuij, I. ; De Vriendt, T. ; Matthys, C. ; Vereecken, C. ; de Maeyer, M. ; Ottevaere, C. ; Huybrechts, I. ; Widhalm, K. ; Phillipp, K. ; Dietrich, S. ; Manios, Y. ; Grammatikaki, E. ; Bouloubasi, Z. ; Cook, T. L. ; Eleutheriou, S. ; Consta, O. ; Moschonis, G. ; Katsaroli, I. ; Kraniou, G. ; Papoutsou, S. ; Keke, D. ; Petraki, I. ; Bellou, E. ; Tanagra, S. ; Kallianoti, K. ; Argyropoulou, D. ; Tsikrika, S. ; Karaiskos, C. ; Meirhaeghe, A. ; Ortega, F. B. ; Hagströmer, M. ; Wennlöf, A. H. ; Hallström, L. ; Patterson, E. ; Kwak, L. ; Rizzo, N. ; Sánchez-Molero, J. ; Picó, E. ; Navarro, M. ; Viadel, B. ; Carreres, J. E. ; Merino, G. ; Sanjuán, R. ; Lorente, M. ; Sánchez, M. J. ; Thomas, S. ; Allchurch, E. ; Burgess, P. ; Astrom, A. ; Sverkén, A. ; Broberg, A. ; Masson, A. ; Lehoux, C. ; Brabant, P. ; Pate, P. ; Fontaine, L. ; Sebok, A. ; Kuti, T. ; Hegyi, A. ; Maldonado, C. ; Llorente, A. ; García, E. ; von Fircks, H. ; Hallberg, M. L. ; Messerer, M. ; Larsson, M. ; Fredriksson, H. ; Adamsson, V. ; Börjesson, I. ; Fernández, L. ; Smillie, L. ; Wills, J. ; Pedrero-Chamizo, R. ; Meléndez, A. ; Valtueña, J. ; Albers, U. ; Benito, P. J. ; Gómez Lorente, J. J. ; Cañada, D. ; Urzanqui, A. ; Torres, R. M. ; Navarro, P. / Ideal cardiovascular health and inflammation in European adolescents : The HELENA study. In: Nutrition, Metabolism and Cardiovascular Diseases. 2017 ; Vol. 27, No. 5. pp. 447-455.
@article{1a7e61d37a4f4b80b45302e0916929db,
title = "Ideal cardiovascular health and inflammation in European adolescents: The HELENA study",
abstract = "Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents. Methods and results As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1{\%} in girls. Conclusion Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.",
keywords = "Cardiovascular health, European adolescents, Inflammation",
author = "Gonz{\'a}lez-Gil, {E. M.} and J. Santab{\'a}rbara and Ruiz, {J. R.} and S. Bel-Serrat and I. Huybrechts and R. Pedrero-Chamizo and {de la O}, A. and F. Gottrand and A. Kafatos and K. Widhalm and Y. Manios and D. Moln{\'a}r and {De Henauw}, S. and M. Plada and M. Ferrari and {Palacios Le Bl{\'e}}, G. and A. Siani and M. Gonz{\'a}lez-Gross and S. G{\'o}mez-Mart{\'i}nez and A. Marcos and {Moreno Aznar}, {L. A.} and Moreno, {L. A.} and F. Gottrand and {De Henauw}, S. and M. Gonz{\'a}lez-Gross and C. Gilbert and A. Kafatos and C. Libersa and S. Castell{\'o} and M. Kersting and M. Sj{\"o}strom and D. Moln{\'a}r and J. Dallongeville and G. Hall and L. Maes and L. Scalfi and P. Mel{\'e}ndez and J. Fleta and Casaj{\'u}s, {J. A.} and G. Rodr{\'i}guez and C. Tom{\'a}s and Mesana, {M. I.} and G. Vicente-Rodr{\'i}guez and A. Villarroya and Gil, {C. M.} and I. Ara and Alvira, {J. F.} and G. Bueno and A. L{\'a}zaro and O. Bueno and Le{\'o}n, {J. F.} and Garagorri, {J. M.} and M. Bueno and I. Labayen and I. Iglesia and {Bel Serrat}, S. and {Gracia Marco}, {L. A.} and T. Mouratidou and A. Santaliestra-Pas{\'i}as and Gonz{\'a}lez-Gil, {E. M.} and {De Miguel-Etayo}, P. and {Juli{\'a}n Alm{\'a}rcegui}, C. and M. Miguel-Berges and I. Iguacel and A. Marcos and J. W{\"a}rnberg and E. Nova and S. G{\'o}mez and D{\'i}az, {L. E.} and J. Romeo and A. Veses and B. Zapatera and T. Pozo and D. Mart{\'i}nez and L. Beghin and F. Gottrand and C. Iliescu and {Von Berlepsch}, J. and W. Sichert-Hellert and E. Koeppen and D. Molnar and E. Erhardt and K. Csernus and K. T{\"o}r{\"o}k and S. Bokor and Angster and E. Nagy and O. Kov{\'a}cs and J. R{\'e}pasi and C. Codrington and M. Plada and A. Papadaki and K. Sarri and A. Viskadourou and C. Hatzis and M. Kiriakakis and G. Tsibinos and C. Vardavas and M. Sbokos and E. Protoyeraki and M. Fasoulaki and P. Stehle and K. Pietrzik and C. Breidenassel and A. Spinneker and J. Al-Tahan and M. Segoviano and A. Berchtold and C. Bierschbach and E. Blatzheim and A. Schuch and P. Pickert and Castillo, {M. J.} and Guti{\'e}rrez and Ortega, {F. B.} and Ruiz, {J. R.} and Artero, {E. G.} and V. Espa{\~n}a and D. Jim{\'e}nez-Pav{\'o}n and P. Chill{\'o}n and C. S{\'a}nchez-Mu{\~n}oz and M. Cuenca and D. Arcella and E. Azzini and E. Barrison and N. Bevilacqua and P. Buonocore and G. Catasta and L. Censi and D. Ciarapica and P. D'Acapito and M. Ferrari and M. Galfo and {Le Donne}, C. and C. Leclercq and G. Maiani and B. Mauro and L. Mistura and A. Pasquali and R. Piccinelli and A. Polito and R. Roccaldo and R. Spada and S. Sette and M. Zaccaria and P. Vitaglione and C. Montagnese and {De Bourdeaudhuij}, I. and {De Vriendt}, T. and C. Matthys and C. Vereecken and {de Maeyer}, M. and C. Ottevaere and I. Huybrechts and K. Widhalm and K. Phillipp and S. Dietrich and Y. Manios and E. Grammatikaki and Z. Bouloubasi and Cook, {T. L.} and S. Eleutheriou and O. Consta and G. Moschonis and I. Katsaroli and G. Kraniou and S. Papoutsou and D. Keke and I. Petraki and E. Bellou and S. Tanagra and K. Kallianoti and D. Argyropoulou and S. Tsikrika and C. Karaiskos and A. Meirhaeghe and Ortega, {F. B.} and M. Hagstr{\"o}mer and Wennl{\"o}f, {A. H.} and L. Hallstr{\"o}m and E. Patterson and L. Kwak and N. Rizzo and J. S{\'a}nchez-Molero and E. Pic{\'o} and M. Navarro and B. Viadel and Carreres, {J. E.} and G. Merino and R. Sanju{\'a}n and M. Lorente and S{\'a}nchez, {M. J.} and S. Thomas and E. Allchurch and P. Burgess and A. Astrom and A. Sverk{\'e}n and A. Broberg and A. Masson and C. Lehoux and P. Brabant and P. Pate and L. Fontaine and A. Sebok and T. Kuti and A. Hegyi and C. Maldonado and A. Llorente and E. Garc{\'i}a and {von Fircks}, H. and Hallberg, {M. L.} and M. Messerer and M. Larsson and H. Fredriksson and V. Adamsson and I. B{\"o}rjesson and L. Fern{\'a}ndez and L. Smillie and J. Wills and R. Pedrero-Chamizo and A. Mel{\'e}ndez and J. Valtue{\~n}a and U. Albers and Benito, {P. J.} and {G{\'o}mez Lorente}, {J. J.} and D. Ca{\~n}ada and A. Urzanqui and Torres, {R. M.} and P. Navarro",
year = "2017",
month = "5",
day = "1",
doi = "10.1016/j.numecd.2016.12.003",
language = "English",
volume = "27",
pages = "447--455",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - Ideal cardiovascular health and inflammation in European adolescents

T2 - The HELENA study

AU - González-Gil, E. M.

AU - Santabárbara, J.

AU - Ruiz, J. R.

AU - Bel-Serrat, S.

AU - Huybrechts, I.

AU - Pedrero-Chamizo, R.

AU - de la O, A.

AU - Gottrand, F.

AU - Kafatos, A.

AU - Widhalm, K.

AU - Manios, Y.

AU - Molnár, D.

AU - De Henauw, S.

AU - Plada, M.

AU - Ferrari, M.

AU - Palacios Le Blé, G.

AU - Siani, A.

AU - González-Gross, M.

AU - Gómez-Martínez, S.

AU - Marcos, A.

AU - Moreno Aznar, L. A.

AU - Moreno, L. A.

AU - Gottrand, F.

AU - De Henauw, S.

AU - González-Gross, M.

AU - Gilbert, C.

AU - Kafatos, A.

AU - Libersa, C.

AU - Castelló, S.

AU - Kersting, M.

AU - Sjöstrom, M.

AU - Molnár, D.

AU - Dallongeville, J.

AU - Hall, G.

AU - Maes, L.

AU - Scalfi, L.

AU - Meléndez, P.

AU - Fleta, J.

AU - Casajús, J. A.

AU - Rodríguez, G.

AU - Tomás, C.

AU - Mesana, M. I.

AU - Vicente-Rodríguez, G.

AU - Villarroya, A.

AU - Gil, C. M.

AU - Ara, I.

AU - Alvira, J. F.

AU - Bueno, G.

AU - Lázaro, A.

AU - Bueno, O.

AU - León, J. F.

AU - Garagorri, J. M.

AU - Bueno, M.

AU - Labayen, I.

AU - Iglesia, I.

AU - Bel Serrat, S.

AU - Gracia Marco, L. A.

AU - Mouratidou, T.

AU - Santaliestra-Pasías, A.

AU - González-Gil, E. M.

AU - De Miguel-Etayo, P.

AU - Julián Almárcegui, C.

AU - Miguel-Berges, M.

AU - Iguacel, I.

AU - Marcos, A.

AU - Wärnberg, J.

AU - Nova, E.

AU - Gómez, S.

AU - Díaz, L. E.

AU - Romeo, J.

AU - Veses, A.

AU - Zapatera, B.

AU - Pozo, T.

AU - Martínez, D.

AU - Beghin, L.

AU - Gottrand, F.

AU - Iliescu, C.

AU - Von Berlepsch, J.

AU - Sichert-Hellert, W.

AU - Koeppen, E.

AU - Molnar, D.

AU - Erhardt, E.

AU - Csernus, K.

AU - Török, K.

AU - Bokor, S.

AU - Angster,

AU - Nagy, E.

AU - Kovács, O.

AU - Répasi, J.

AU - Codrington, C.

AU - Plada, M.

AU - Papadaki, A.

AU - Sarri, K.

AU - Viskadourou, A.

AU - Hatzis, C.

AU - Kiriakakis, M.

AU - Tsibinos, G.

AU - Vardavas, C.

AU - Sbokos, M.

AU - Protoyeraki, E.

AU - Fasoulaki, M.

AU - Stehle, P.

AU - Pietrzik, K.

AU - Breidenassel, C.

AU - Spinneker, A.

AU - Al-Tahan, J.

AU - Segoviano, M.

AU - Berchtold, A.

AU - Bierschbach, C.

AU - Blatzheim, E.

AU - Schuch, A.

AU - Pickert, P.

AU - Castillo, M. J.

AU - Gutiérrez,

AU - Ortega, F. B.

AU - Ruiz, J. R.

AU - Artero, E. G.

AU - España, V.

AU - Jiménez-Pavón, D.

AU - Chillón, P.

AU - Sánchez-Muñoz, C.

AU - Cuenca, M.

AU - Arcella, D.

AU - Azzini, E.

AU - Barrison, E.

AU - Bevilacqua, N.

AU - Buonocore, P.

AU - Catasta, G.

AU - Censi, L.

AU - Ciarapica, D.

AU - D'Acapito, P.

AU - Ferrari, M.

AU - Galfo, M.

AU - Le Donne, C.

AU - Leclercq, C.

AU - Maiani, G.

AU - Mauro, B.

AU - Mistura, L.

AU - Pasquali, A.

AU - Piccinelli, R.

AU - Polito, A.

AU - Roccaldo, R.

AU - Spada, R.

AU - Sette, S.

AU - Zaccaria, M.

AU - Vitaglione, P.

AU - Montagnese, C.

AU - De Bourdeaudhuij, I.

AU - De Vriendt, T.

AU - Matthys, C.

AU - Vereecken, C.

AU - de Maeyer, M.

AU - Ottevaere, C.

AU - Huybrechts, I.

AU - Widhalm, K.

AU - Phillipp, K.

AU - Dietrich, S.

AU - Manios, Y.

AU - Grammatikaki, E.

AU - Bouloubasi, Z.

AU - Cook, T. L.

AU - Eleutheriou, S.

AU - Consta, O.

AU - Moschonis, G.

AU - Katsaroli, I.

AU - Kraniou, G.

AU - Papoutsou, S.

AU - Keke, D.

AU - Petraki, I.

AU - Bellou, E.

AU - Tanagra, S.

AU - Kallianoti, K.

AU - Argyropoulou, D.

AU - Tsikrika, S.

AU - Karaiskos, C.

AU - Meirhaeghe, A.

AU - Ortega, F. B.

AU - Hagströmer, M.

AU - Wennlöf, A. H.

AU - Hallström, L.

AU - Patterson, E.

AU - Kwak, L.

AU - Rizzo, N.

AU - Sánchez-Molero, J.

AU - Picó, E.

AU - Navarro, M.

AU - Viadel, B.

AU - Carreres, J. E.

AU - Merino, G.

AU - Sanjuán, R.

AU - Lorente, M.

AU - Sánchez, M. J.

AU - Thomas, S.

AU - Allchurch, E.

AU - Burgess, P.

AU - Astrom, A.

AU - Sverkén, A.

AU - Broberg, A.

AU - Masson, A.

AU - Lehoux, C.

AU - Brabant, P.

AU - Pate, P.

AU - Fontaine, L.

AU - Sebok, A.

AU - Kuti, T.

AU - Hegyi, A.

AU - Maldonado, C.

AU - Llorente, A.

AU - García, E.

AU - von Fircks, H.

AU - Hallberg, M. L.

AU - Messerer, M.

AU - Larsson, M.

AU - Fredriksson, H.

AU - Adamsson, V.

AU - Börjesson, I.

AU - Fernández, L.

AU - Smillie, L.

AU - Wills, J.

AU - Pedrero-Chamizo, R.

AU - Meléndez, A.

AU - Valtueña, J.

AU - Albers, U.

AU - Benito, P. J.

AU - Gómez Lorente, J. J.

AU - Cañada, D.

AU - Urzanqui, A.

AU - Torres, R. M.

AU - Navarro, P.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents. Methods and results As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1% in girls. Conclusion Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.

AB - Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents. Methods and results As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1% in girls. Conclusion Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.

KW - Cardiovascular health

KW - European adolescents

KW - Inflammation

UR - http://www.scopus.com/inward/record.url?scp=85017439998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017439998&partnerID=8YFLogxK

U2 - 10.1016/j.numecd.2016.12.003

DO - 10.1016/j.numecd.2016.12.003

M3 - Article

C2 - 28416098

AN - SCOPUS:85017439998

VL - 27

SP - 447

EP - 455

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 5

ER -