Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica

Robert Wagner, Ursel Leicht-Biener, I. Mucsi, Karlheinz Seitz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective. In many parts of Europe, nephropathia epidemica (NE) is an endemic zoonosis. After a flu-like prodrome, this viral disease often manifests with acute kidney injury. Use of non-steroidal anti-inflammatory drugs is discouraged during the disease, but no data from clinical investigations are available on the association between disease course and the use of analgesics. Material and methods. The charts of 59 patients admitted with NE to a hospital in 2007 were retrospectively analysed. Creatinine levels were compared between users of different analgesics. Results. Patients taking analgesics before admission had higher peak creatinine levels, but not after adjustment for confounders. The subgroup taking ibuprofen or diclofenac had higher initial and peak creatinine levels than the group who did not, even after adjustment for confounders. Conclusion. Since NE cannot be accurately diagnosed in the early disease phase, metamizole, acetaminophen or acetylsalicylic acid may be preferable analgesics to ibuprofen or diclofenac for flu-like symptoms in endemic areas.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalScandinavian Journal of Urology and Nephrology
Volume46
Issue number1
DOIs
Publication statusPublished - Feb 2012

Fingerprint

Hemorrhagic Fever with Renal Syndrome
Diclofenac
Ibuprofen
Acute Kidney Injury
Analgesics
Creatinine
Dipyrone
Zoonoses
Virus Diseases
Acetaminophen
Aspirin
Anti-Inflammatory Agents
Pharmaceutical Preparations

Keywords

  • Acute kidney injury
  • Analgesics
  • Diclofenac
  • Ibuprofen
  • Nephropathia epidemica
  • Non-steroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Ibuprofen or diclofenac is associated with more severe acute kidney injury in nephropathia epidemica. / Wagner, Robert; Leicht-Biener, Ursel; Mucsi, I.; Seitz, Karlheinz.

In: Scandinavian Journal of Urology and Nephrology, Vol. 46, No. 1, 02.2012, p. 65-69.

Research output: Contribution to journalArticle

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