Iatrogenic multiple pregnancy: Higher risk than a spontaneous one?

Ildikó Nyirati, Hajnalka Orvos, György Bártfai, László Kovács

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OBJECTIVE: To determine if spontaneous and induced multiple pregnancies have similar outcomes. STUDY DESIGN: We compared the results of antepartum and intrapartum surveillance and fetal outcome in spontaneous multiple gestations (group A) with induced multiple gestations (group B) at Albert Szent-Gyorgyi Medical University, Szeged, Hungary, in a six-year period. RESULTS: Between January 1, 1991, and December 31, 1996, there were 13,131 births; the number of multiple pregnancies was 307 (2.34%). There were 232 spontaneous and 48 induced twin pregnancies, 8 spontaneous and 16 induced triplet pregnancies, and 3 quadruplet pregnancies, all induced. Higher incidences of gestational diabetes and cervical insufficiency were found in group B. The incidences of prematurity in the induced and spontaneous groups were similar. The incidences of low birth weight and perinatal mortality were higher in induced triplet pregnancies than in spontaneous ones. Fetal outcome, with respect to Apgar score and umbilical cord blood pH, was much poorer in both induced groups. CONCLUSION: Iatrogenic multiple pregnancy following ovulation induction or assisted operative reproductive techniques may increase the incidence of pathologic events in the antepartum, intrapartum or postpartum period. Careful counseling before assisted reproductive techniques is of paramount importance.

Original languageEnglish
Pages (from-to)695-698
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number11
Publication statusPublished - Nov 1 1997



  • Pregnancy complications
  • Pregnancy, multiple
  • Twins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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