Hypoxia and hypoxia inducible factors: Diverse roles in liver diseases

Bharath Nath, G. Szabó

Research output: Contribution to journalReview article

138 Citations (Scopus)

Abstract

Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as other liver diseases in both human disease as well as murine models.

Original languageEnglish
Pages (from-to)622-633
Number of pages12
JournalHepatology
Volume55
Issue number2
DOIs
Publication statusPublished - Feb 2012

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Liver Diseases
Inflammation Mediators
Liver Cirrhosis
Hepatocellular Carcinoma
Hypoxia
Oxygen
Liver

ASJC Scopus subject areas

  • Hepatology

Cite this

Hypoxia and hypoxia inducible factors : Diverse roles in liver diseases. / Nath, Bharath; Szabó, G.

In: Hepatology, Vol. 55, No. 2, 02.2012, p. 622-633.

Research output: Contribution to journalReview article

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