Hypothalamus and puberty

Béla Halász, Katalin Köves, Judith Molnár, Katalin Balika, Viktoria Stoll, Gábor Kovács

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The effect of a transitory increase in plasma FSH and LH levels during the prepubertal period on puberty has been investigated. Twenty-day-old rats had been bilaterally ovariectomized and 24 hr later they received two ovaries of infantile rats beneath the kidney capsule. These rats exhibited precocious puberty. Animals into which two additional ovaries had been transplanted first and the next day their own ovaries removed showed puberty at the same time as controls. Additional investigations provided evidence that in the ovariectomized and ovary implanted rats plasma FSH and LH levels were in the control range four days after implantation. The findings support the assumption that the hypothalamic lesion-induced precocious puberty is due rather to a transitory enhanced release of gonadotropin releasing hormone by the lesion than to the destruction of sex-steroid sensitive structures inhibiting the release of gonadotropic hormones in prepubertal rats.

Original languageEnglish
Pages (from-to)709-712
Number of pages4
JournalBrain Research Bulletin
Issue number6
Publication statusPublished - Jun 1988



  • Gonadotropic hormones
  • Hypothalamus
  • Puberty

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Halász, B., Köves, K., Molnár, J., Balika, K., Stoll, V., & Kovács, G. (1988). Hypothalamus and puberty. Brain Research Bulletin, 20(6), 709-712. https://doi.org/10.1016/0361-9230(88)90081-0