Hyponatremia and increased secretion of vasopressin induced by vincristine administration in rat

I. Jojart, F. Laczi, F. László, K. Boda, S. Csati, T. Janáky

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Administration of vincristine resulted in a hyponatremic state and concurrent elevation of the plasma immunoreactive arginine-vasopressin (IR-AVP) level in rats. Development of the vincristine-induced hyponatremia and hypoosmolality was accompanied by a loss in weight, a decreased water intake and a large reduction in the daily urine sodium excretion. The cause of the sodium loss is thought to be the diarrhea observed during vincristine treatment. Hematocrit and serum urea nitrogen levels were increased. It is concluded that the condition differs from the syndrome of inaproppriate secretion of antidiuretic hormone (SIADH): the increase in plasma IR-AVP concentration may be associated with dehydration due to vincristine toxicity.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalExperimental and Clinical Endocrinology
Volume90
Issue number2
Publication statusPublished - 1987

Fingerprint

Hyponatremia
Vincristine
Vasopressins
Arginine Vasopressin
Sodium
Dehydration
Hematocrit
Drinking
Urea
Weight Loss
Diarrhea
Nitrogen
Urine
Serum
Therapeutics

ASJC Scopus subject areas

  • Endocrinology

Cite this

Hyponatremia and increased secretion of vasopressin induced by vincristine administration in rat. / Jojart, I.; Laczi, F.; László, F.; Boda, K.; Csati, S.; Janáky, T.

In: Experimental and Clinical Endocrinology, Vol. 90, No. 2, 1987, p. 213-220.

Research output: Contribution to journalArticle

@article{c8c2a0c3387d4ef4bb22771d282b7a66,
title = "Hyponatremia and increased secretion of vasopressin induced by vincristine administration in rat",
abstract = "Administration of vincristine resulted in a hyponatremic state and concurrent elevation of the plasma immunoreactive arginine-vasopressin (IR-AVP) level in rats. Development of the vincristine-induced hyponatremia and hypoosmolality was accompanied by a loss in weight, a decreased water intake and a large reduction in the daily urine sodium excretion. The cause of the sodium loss is thought to be the diarrhea observed during vincristine treatment. Hematocrit and serum urea nitrogen levels were increased. It is concluded that the condition differs from the syndrome of inaproppriate secretion of antidiuretic hormone (SIADH): the increase in plasma IR-AVP concentration may be associated with dehydration due to vincristine toxicity.",
author = "I. Jojart and F. Laczi and F. L{\'a}szl{\'o} and K. Boda and S. Csati and T. Jan{\'a}ky",
year = "1987",
language = "English",
volume = "90",
pages = "213--220",
journal = "Experimental and Clinical Endocrinology and Diabetes",
issn = "0947-7349",
publisher = "Thieme",
number = "2",

}

TY - JOUR

T1 - Hyponatremia and increased secretion of vasopressin induced by vincristine administration in rat

AU - Jojart, I.

AU - Laczi, F.

AU - László, F.

AU - Boda, K.

AU - Csati, S.

AU - Janáky, T.

PY - 1987

Y1 - 1987

N2 - Administration of vincristine resulted in a hyponatremic state and concurrent elevation of the plasma immunoreactive arginine-vasopressin (IR-AVP) level in rats. Development of the vincristine-induced hyponatremia and hypoosmolality was accompanied by a loss in weight, a decreased water intake and a large reduction in the daily urine sodium excretion. The cause of the sodium loss is thought to be the diarrhea observed during vincristine treatment. Hematocrit and serum urea nitrogen levels were increased. It is concluded that the condition differs from the syndrome of inaproppriate secretion of antidiuretic hormone (SIADH): the increase in plasma IR-AVP concentration may be associated with dehydration due to vincristine toxicity.

AB - Administration of vincristine resulted in a hyponatremic state and concurrent elevation of the plasma immunoreactive arginine-vasopressin (IR-AVP) level in rats. Development of the vincristine-induced hyponatremia and hypoosmolality was accompanied by a loss in weight, a decreased water intake and a large reduction in the daily urine sodium excretion. The cause of the sodium loss is thought to be the diarrhea observed during vincristine treatment. Hematocrit and serum urea nitrogen levels were increased. It is concluded that the condition differs from the syndrome of inaproppriate secretion of antidiuretic hormone (SIADH): the increase in plasma IR-AVP concentration may be associated with dehydration due to vincristine toxicity.

UR - http://www.scopus.com/inward/record.url?scp=0023641184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023641184&partnerID=8YFLogxK

M3 - Article

VL - 90

SP - 213

EP - 220

JO - Experimental and Clinical Endocrinology and Diabetes

JF - Experimental and Clinical Endocrinology and Diabetes

SN - 0947-7349

IS - 2

ER -