Hypolipaemic effect and inhibition of lipid peroxidation by glunicate in rats on atherogenic diet

J. Fehér, A. Kiss, A. Blázovics, E. Szondy, H. Toncsev, D. Mathiász, S. Gerö

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The antiatherosclerotic profile of nicotinic acid and of its new water-insoluble derivative was studied in an 8-day experiment in rats. Both drugs lowered plasma triglyceride levels significantly, while other lipoprotein parameters were unaffected. Circulating immune complex levels were decreased with lysosomal membrane permeability by both drugs. Glunicate proved to be a powerful antioxidant with regard to enzymatic lipid peroxidation when studied in the liver microsomal system. The relevance of these findings to the antiatherosclerotic effect of the drugs and the biological significance of antioxidant treatment is discussed. On the basis of these data glunicate seems to be a promising new therapeutic tool against atherosclerosis and merits further study.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalDrugs under Experimental and Clinical Research
Volume11
Issue number6
Publication statusPublished - 1985

Fingerprint

Atherogenic Diet
Lipid Peroxidation
Antioxidants
Pharmaceutical Preparations
Niacin
Antigen-Antibody Complex
Lipoproteins
Permeability
Atherosclerosis
Triglycerides
Membranes
Water
Liver
glunicate
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology
  • Drug Discovery

Cite this

Hypolipaemic effect and inhibition of lipid peroxidation by glunicate in rats on atherogenic diet. / Fehér, J.; Kiss, A.; Blázovics, A.; Szondy, E.; Toncsev, H.; Mathiász, D.; Gerö, S.

In: Drugs under Experimental and Clinical Research, Vol. 11, No. 6, 1985, p. 413-419.

Research output: Contribution to journalArticle

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