Hypertrophic response of the kidney in indomethacin treated rats

P. Vasadi, L. Selmeci, E. Posch, L. Hársing

Research output: Contribution to journalArticle

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Abstract

Indomethacin, a potent inhibitor of prostaglandin (PG) synthesis administered to rats in a total dose of 2 x 4.5 mg/kg i.v. for 2 days, enhanced compensatory renal hypertrophy following unilateral nephrectomy (UN). The same drug given to rats with intact kidneys in a total dose of 4 x 4.5 mg/kg i.p. in 2 days increased kidney weight, renal RNA content and decreased renal acidic ribonuclease activity. It remains to be elucidated whether the suppression of PG synthesis and/or other pharmacological effects of indomethacin account for these findings.

Original languageEnglish
Pages (from-to)427-432
Number of pages6
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume53
Issue number4
Publication statusPublished - 1979

Fingerprint

Indomethacin
Kidney
Prostaglandin Antagonists
Ribonucleases
Nephrectomy
Hypertrophy
Prostaglandins
Pharmacology
RNA
Weights and Measures
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Physiology

Cite this

Hypertrophic response of the kidney in indomethacin treated rats. / Vasadi, P.; Selmeci, L.; Posch, E.; Hársing, L.

In: Acta Physiologica Academiae Scientiarum Hungaricae, Vol. 53, No. 4, 1979, p. 427-432.

Research output: Contribution to journalArticle

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