Hypertrophic cardiomyopathy is associated with abnormal echocardiographic aortic elastic properties and arteriograph-derived pulse-wave velocity

Henriette Gavallér, Róbert Sepp, M. Csanády, T. Forster, Attila Nemes

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease and defined by the presence of unexplained left ventricular hypertrophy (LVH). Vascular alterations are frequently associated with HCM including microvascular and/or peripherial endothelial dysfunction. This study was designed to evaluate echocardiographic ascending aortic elastic properties and arteriograph-derived pulse-wave velocity (PWV) and augmentation index (Aix) in HCM. Methods: This study comprised 38 patients with typical features of HCM. Their results were compared to 20 hypertensive patients with LVH and 23 controls. Systolic and diastolic ascending aortic diameters were recorded in M-mode at a level of 3 cm above the aortic valve from a parasternal long-axis view. The following echocardiographic aortic elastic properties were measured from aortic data and forearm blood pressure values: aortic strain, distensibility, and stiffness index. Arteriograph-derived PWV and AIx were also measured. Results: Aortic stiffness index (18.4 ± 17.6 vs. 6.88 ± 3.63, P <0.05), PWV (9.44 ± 4.08 vs. 7.97 ± 1.20 m/sec, P <0.05) and Aix (-24.9 ± 32.6 vs. -41.4 ± 24.3, P <0.05) were increased, while aortic strain (0.061 ± 0.053 vs. 0.100 ± 0.059, P <0.05) and aortic distensibility (1.94 ± 1.68 cm 2/dynes 10 -6 vs. 3.08 ± 1.77 cm 2/dynes 10 -6, P <0.05) were decreased in HCM patients compared to controls. Aortic elastic properties of hypertensive patients with LVH showed similar alterations to HCM patients. Conclusions: Abnormal echocardiographic aortic elastic properties and arteriograph-derived PWV and Aix could be demonstrated in HCM patients compared to matched controls.

Original languageEnglish
Pages (from-to)848-852
Number of pages5
JournalEchocardiography
Volume28
Issue number8
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Pulse Wave Analysis
Hypertrophic Cardiomyopathy
Left Ventricular Hypertrophy
Inborn Genetic Diseases
Vascular Stiffness
Aortic Valve
Forearm
Blood Vessels
Heart Diseases
Arterial Pressure

Keywords

  • aortic
  • distensibility
  • echocardiography
  • hypertrophic cardiomyopathy
  • stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Hypertrophic cardiomyopathy is associated with abnormal echocardiographic aortic elastic properties and arteriograph-derived pulse-wave velocity. / Gavallér, Henriette; Sepp, Róbert; Csanády, M.; Forster, T.; Nemes, Attila.

In: Echocardiography, Vol. 28, No. 8, 09.2011, p. 848-852.

Research output: Contribution to journalArticle

@article{2b7e08d977aa44e4bd8e65ba1cba537d,
title = "Hypertrophic cardiomyopathy is associated with abnormal echocardiographic aortic elastic properties and arteriograph-derived pulse-wave velocity",
abstract = "Objective: Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease and defined by the presence of unexplained left ventricular hypertrophy (LVH). Vascular alterations are frequently associated with HCM including microvascular and/or peripherial endothelial dysfunction. This study was designed to evaluate echocardiographic ascending aortic elastic properties and arteriograph-derived pulse-wave velocity (PWV) and augmentation index (Aix) in HCM. Methods: This study comprised 38 patients with typical features of HCM. Their results were compared to 20 hypertensive patients with LVH and 23 controls. Systolic and diastolic ascending aortic diameters were recorded in M-mode at a level of 3 cm above the aortic valve from a parasternal long-axis view. The following echocardiographic aortic elastic properties were measured from aortic data and forearm blood pressure values: aortic strain, distensibility, and stiffness index. Arteriograph-derived PWV and AIx were also measured. Results: Aortic stiffness index (18.4 ± 17.6 vs. 6.88 ± 3.63, P <0.05), PWV (9.44 ± 4.08 vs. 7.97 ± 1.20 m/sec, P <0.05) and Aix (-24.9 ± 32.6 vs. -41.4 ± 24.3, P <0.05) were increased, while aortic strain (0.061 ± 0.053 vs. 0.100 ± 0.059, P <0.05) and aortic distensibility (1.94 ± 1.68 cm 2/dynes 10 -6 vs. 3.08 ± 1.77 cm 2/dynes 10 -6, P <0.05) were decreased in HCM patients compared to controls. Aortic elastic properties of hypertensive patients with LVH showed similar alterations to HCM patients. Conclusions: Abnormal echocardiographic aortic elastic properties and arteriograph-derived PWV and Aix could be demonstrated in HCM patients compared to matched controls.",
keywords = "aortic, distensibility, echocardiography, hypertrophic cardiomyopathy, stiffness",
author = "Henriette Gavall{\'e}r and R{\'o}bert Sepp and M. Csan{\'a}dy and T. Forster and Attila Nemes",
year = "2011",
month = "9",
doi = "10.1111/j.1540-8175.2011.01469.x",
language = "English",
volume = "28",
pages = "848--852",
journal = "Echocardiography",
issn = "0742-2822",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Hypertrophic cardiomyopathy is associated with abnormal echocardiographic aortic elastic properties and arteriograph-derived pulse-wave velocity

AU - Gavallér, Henriette

AU - Sepp, Róbert

AU - Csanády, M.

AU - Forster, T.

AU - Nemes, Attila

PY - 2011/9

Y1 - 2011/9

N2 - Objective: Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease and defined by the presence of unexplained left ventricular hypertrophy (LVH). Vascular alterations are frequently associated with HCM including microvascular and/or peripherial endothelial dysfunction. This study was designed to evaluate echocardiographic ascending aortic elastic properties and arteriograph-derived pulse-wave velocity (PWV) and augmentation index (Aix) in HCM. Methods: This study comprised 38 patients with typical features of HCM. Their results were compared to 20 hypertensive patients with LVH and 23 controls. Systolic and diastolic ascending aortic diameters were recorded in M-mode at a level of 3 cm above the aortic valve from a parasternal long-axis view. The following echocardiographic aortic elastic properties were measured from aortic data and forearm blood pressure values: aortic strain, distensibility, and stiffness index. Arteriograph-derived PWV and AIx were also measured. Results: Aortic stiffness index (18.4 ± 17.6 vs. 6.88 ± 3.63, P <0.05), PWV (9.44 ± 4.08 vs. 7.97 ± 1.20 m/sec, P <0.05) and Aix (-24.9 ± 32.6 vs. -41.4 ± 24.3, P <0.05) were increased, while aortic strain (0.061 ± 0.053 vs. 0.100 ± 0.059, P <0.05) and aortic distensibility (1.94 ± 1.68 cm 2/dynes 10 -6 vs. 3.08 ± 1.77 cm 2/dynes 10 -6, P <0.05) were decreased in HCM patients compared to controls. Aortic elastic properties of hypertensive patients with LVH showed similar alterations to HCM patients. Conclusions: Abnormal echocardiographic aortic elastic properties and arteriograph-derived PWV and Aix could be demonstrated in HCM patients compared to matched controls.

AB - Objective: Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease and defined by the presence of unexplained left ventricular hypertrophy (LVH). Vascular alterations are frequently associated with HCM including microvascular and/or peripherial endothelial dysfunction. This study was designed to evaluate echocardiographic ascending aortic elastic properties and arteriograph-derived pulse-wave velocity (PWV) and augmentation index (Aix) in HCM. Methods: This study comprised 38 patients with typical features of HCM. Their results were compared to 20 hypertensive patients with LVH and 23 controls. Systolic and diastolic ascending aortic diameters were recorded in M-mode at a level of 3 cm above the aortic valve from a parasternal long-axis view. The following echocardiographic aortic elastic properties were measured from aortic data and forearm blood pressure values: aortic strain, distensibility, and stiffness index. Arteriograph-derived PWV and AIx were also measured. Results: Aortic stiffness index (18.4 ± 17.6 vs. 6.88 ± 3.63, P <0.05), PWV (9.44 ± 4.08 vs. 7.97 ± 1.20 m/sec, P <0.05) and Aix (-24.9 ± 32.6 vs. -41.4 ± 24.3, P <0.05) were increased, while aortic strain (0.061 ± 0.053 vs. 0.100 ± 0.059, P <0.05) and aortic distensibility (1.94 ± 1.68 cm 2/dynes 10 -6 vs. 3.08 ± 1.77 cm 2/dynes 10 -6, P <0.05) were decreased in HCM patients compared to controls. Aortic elastic properties of hypertensive patients with LVH showed similar alterations to HCM patients. Conclusions: Abnormal echocardiographic aortic elastic properties and arteriograph-derived PWV and Aix could be demonstrated in HCM patients compared to matched controls.

KW - aortic

KW - distensibility

KW - echocardiography

KW - hypertrophic cardiomyopathy

KW - stiffness

UR - http://www.scopus.com/inward/record.url?scp=81155161823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81155161823&partnerID=8YFLogxK

U2 - 10.1111/j.1540-8175.2011.01469.x

DO - 10.1111/j.1540-8175.2011.01469.x

M3 - Article

C2 - 21827547

AN - SCOPUS:81155161823

VL - 28

SP - 848

EP - 852

JO - Echocardiography

JF - Echocardiography

SN - 0742-2822

IS - 8

ER -