Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level

János Nemcsik, Andrea László, Lilla Lénárt, Dániel Eörsi, Péter Torzsa, Beáta Korösi, Orsolya Cseprekál, András Tislér, Ádám Tabák, X. Gonda, Z. Ríhmer, Judit Hodrea, Zsófia Nemcsik-Bencze, Andrea Fekete

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Brain-derived neurotrophic factor (BDNF) has neuroprotective, proangiogenic and myogenic effects and, therefore, possibly acts as a psychosomatic mediator. Here, we measured serum BDNF (seBDNF) level in hypertensive patients (HT) and healthy controls (CONT) and its relation to affective temperaments, depression and anxiety scales, and arterial stiffness parameters. Methods: In this cross-sectional study, affective temperaments, anxiety, and depression were studied with questionnaires (TEMPS-A, HAM-A, and BDI, respectively). SeBDNF level and routine laboratory parameters were measured as well. Arterial stiffness was evaluated with a tonometric method. Results: Allover, 151 HT, and 32 CONT subjects were involved in the study. SeBDNF level was significantly higher in HT compared to CONT (24880 ± 8279 vs 21202.6 ± 6045.5 pg/mL, p < 0.05). In the final model of regression analysis, hyperthymic temperament score (Beta = 405.8, p = 0.004) and the presence of hypertension (Beta = 6121.2, p = 0.001) were independent determinants of seBDNF. In interaction analysis, it was found that in HT, a unit increase in hyperthymic score was associated with a 533.3 (95 %CI 241.3-825.3) pg/mL higher seBDNF. This interaction was missing in CONT. Conclusions: Our results suggest a complex psychosomatic involvement of BDNF in the pathophysiology of hypertension, where hyperthymic affective temperament may have a protective role. BDNF is not likely to have an effect on large arteries.

Original languageEnglish
Article number17
JournalAnnals of General Psychiatry
Volume15
Issue number1
DOIs
Publication statusPublished - Jul 29 2016

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Temperament
Brain-Derived Neurotrophic Factor
Hypertension
Serum
Vascular Stiffness
Anxiety
Depression
Arteries
Cross-Sectional Studies
Regression Analysis

Keywords

  • Affective temperaments
  • Arterial stiffness
  • Brain-derived neurotrophic factor
  • Hypertension

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level. / Nemcsik, János; László, Andrea; Lénárt, Lilla; Eörsi, Dániel; Torzsa, Péter; Korösi, Beáta; Cseprekál, Orsolya; Tislér, András; Tabák, Ádám; Gonda, X.; Ríhmer, Z.; Hodrea, Judit; Nemcsik-Bencze, Zsófia; Fekete, Andrea.

In: Annals of General Psychiatry, Vol. 15, No. 1, 17, 29.07.2016.

Research output: Contribution to journalArticle

Nemcsik, J, László, A, Lénárt, L, Eörsi, D, Torzsa, P, Korösi, B, Cseprekál, O, Tislér, A, Tabák, Á, Gonda, X, Ríhmer, Z, Hodrea, J, Nemcsik-Bencze, Z & Fekete, A 2016, 'Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level', Annals of General Psychiatry, vol. 15, no. 1, 17. https://doi.org/10.1186/s12991-016-0104-4
Nemcsik, János ; László, Andrea ; Lénárt, Lilla ; Eörsi, Dániel ; Torzsa, Péter ; Korösi, Beáta ; Cseprekál, Orsolya ; Tislér, András ; Tabák, Ádám ; Gonda, X. ; Ríhmer, Z. ; Hodrea, Judit ; Nemcsik-Bencze, Zsófia ; Fekete, Andrea. / Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level. In: Annals of General Psychiatry. 2016 ; Vol. 15, No. 1.
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AU - László, Andrea

AU - Lénárt, Lilla

AU - Eörsi, Dániel

AU - Torzsa, Péter

AU - Korösi, Beáta

AU - Cseprekál, Orsolya

AU - Tislér, András

AU - Tabák, Ádám

AU - Gonda, X.

AU - Ríhmer, Z.

AU - Hodrea, Judit

AU - Nemcsik-Bencze, Zsófia

AU - Fekete, Andrea

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N2 - Background: Brain-derived neurotrophic factor (BDNF) has neuroprotective, proangiogenic and myogenic effects and, therefore, possibly acts as a psychosomatic mediator. Here, we measured serum BDNF (seBDNF) level in hypertensive patients (HT) and healthy controls (CONT) and its relation to affective temperaments, depression and anxiety scales, and arterial stiffness parameters. Methods: In this cross-sectional study, affective temperaments, anxiety, and depression were studied with questionnaires (TEMPS-A, HAM-A, and BDI, respectively). SeBDNF level and routine laboratory parameters were measured as well. Arterial stiffness was evaluated with a tonometric method. Results: Allover, 151 HT, and 32 CONT subjects were involved in the study. SeBDNF level was significantly higher in HT compared to CONT (24880 ± 8279 vs 21202.6 ± 6045.5 pg/mL, p < 0.05). In the final model of regression analysis, hyperthymic temperament score (Beta = 405.8, p = 0.004) and the presence of hypertension (Beta = 6121.2, p = 0.001) were independent determinants of seBDNF. In interaction analysis, it was found that in HT, a unit increase in hyperthymic score was associated with a 533.3 (95 %CI 241.3-825.3) pg/mL higher seBDNF. This interaction was missing in CONT. Conclusions: Our results suggest a complex psychosomatic involvement of BDNF in the pathophysiology of hypertension, where hyperthymic affective temperament may have a protective role. BDNF is not likely to have an effect on large arteries.

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