Hyperthermic response to intraventricular injection of scorpion venom

role of brain monoamines

O. H. Osman, M. Ismail, T. Wenger

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Venom obtained from the scorpion Leiurus quinquestriatus produced a pronounced hyperthermic response when injected intraventricularly into rabbits. The venom-induced hyperthermia differed from that of pyrogens by its rapid onset following intraventricular injection and by the absence of the hyperthermic response when the venom was injected intravenously. The hyperthermic response was not antagonized by the prior intraventricular or intravenous injection of scorpion antiserum. Similarly, it was not modified by treatment with either chloropromazine or phenylbutazone. Pretreatment of rabbits with diethyldithio-carbamate or reserpine conferred partial protection against the hyperthermic response to the venom, whereas pretreatment of the rabbits with p-chlorophenylalanine markedly potentiated the response. Pretreatment of the rabbits with methysergide, tolazoline and/or propranolol did not modify the hyperthermic effect of the venom. The venom may act by releasing noradrenaline in the anterior hypothalamus or by causing, in the posterior hypothalamus, a shift in the balance of sodium and calcium.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalToxicon
Volume11
Issue number4
DOIs
Publication statusPublished - 1973

Fingerprint

Scorpion Venoms
Intraventricular Injections
Venoms
Brain
Rabbits
Tolazoline
Posterior Hypothalamus
Fenclonine
Pyrogens
Anterior Hypothalamus
Scorpions
Methysergide
Phenylbutazone
Induced Hyperthermia
Carbamates
Reserpine
Propranolol
Intravenous Injections
Immune Sera
Norepinephrine

ASJC Scopus subject areas

  • Toxicology

Cite this

Hyperthermic response to intraventricular injection of scorpion venom : role of brain monoamines. / Osman, O. H.; Ismail, M.; Wenger, T.

In: Toxicon, Vol. 11, No. 4, 1973, p. 361-368.

Research output: Contribution to journalArticle

@article{1e522fe0a7de43d38319e0aeee5c73da,
title = "Hyperthermic response to intraventricular injection of scorpion venom: role of brain monoamines",
abstract = "Venom obtained from the scorpion Leiurus quinquestriatus produced a pronounced hyperthermic response when injected intraventricularly into rabbits. The venom-induced hyperthermia differed from that of pyrogens by its rapid onset following intraventricular injection and by the absence of the hyperthermic response when the venom was injected intravenously. The hyperthermic response was not antagonized by the prior intraventricular or intravenous injection of scorpion antiserum. Similarly, it was not modified by treatment with either chloropromazine or phenylbutazone. Pretreatment of rabbits with diethyldithio-carbamate or reserpine conferred partial protection against the hyperthermic response to the venom, whereas pretreatment of the rabbits with p-chlorophenylalanine markedly potentiated the response. Pretreatment of the rabbits with methysergide, tolazoline and/or propranolol did not modify the hyperthermic effect of the venom. The venom may act by releasing noradrenaline in the anterior hypothalamus or by causing, in the posterior hypothalamus, a shift in the balance of sodium and calcium.",
author = "Osman, {O. H.} and M. Ismail and T. Wenger",
year = "1973",
doi = "10.1016/0041-0101(73)90034-2",
language = "English",
volume = "11",
pages = "361--368",
journal = "Toxicon",
issn = "0041-0101",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Hyperthermic response to intraventricular injection of scorpion venom

T2 - role of brain monoamines

AU - Osman, O. H.

AU - Ismail, M.

AU - Wenger, T.

PY - 1973

Y1 - 1973

N2 - Venom obtained from the scorpion Leiurus quinquestriatus produced a pronounced hyperthermic response when injected intraventricularly into rabbits. The venom-induced hyperthermia differed from that of pyrogens by its rapid onset following intraventricular injection and by the absence of the hyperthermic response when the venom was injected intravenously. The hyperthermic response was not antagonized by the prior intraventricular or intravenous injection of scorpion antiserum. Similarly, it was not modified by treatment with either chloropromazine or phenylbutazone. Pretreatment of rabbits with diethyldithio-carbamate or reserpine conferred partial protection against the hyperthermic response to the venom, whereas pretreatment of the rabbits with p-chlorophenylalanine markedly potentiated the response. Pretreatment of the rabbits with methysergide, tolazoline and/or propranolol did not modify the hyperthermic effect of the venom. The venom may act by releasing noradrenaline in the anterior hypothalamus or by causing, in the posterior hypothalamus, a shift in the balance of sodium and calcium.

AB - Venom obtained from the scorpion Leiurus quinquestriatus produced a pronounced hyperthermic response when injected intraventricularly into rabbits. The venom-induced hyperthermia differed from that of pyrogens by its rapid onset following intraventricular injection and by the absence of the hyperthermic response when the venom was injected intravenously. The hyperthermic response was not antagonized by the prior intraventricular or intravenous injection of scorpion antiserum. Similarly, it was not modified by treatment with either chloropromazine or phenylbutazone. Pretreatment of rabbits with diethyldithio-carbamate or reserpine conferred partial protection against the hyperthermic response to the venom, whereas pretreatment of the rabbits with p-chlorophenylalanine markedly potentiated the response. Pretreatment of the rabbits with methysergide, tolazoline and/or propranolol did not modify the hyperthermic effect of the venom. The venom may act by releasing noradrenaline in the anterior hypothalamus or by causing, in the posterior hypothalamus, a shift in the balance of sodium and calcium.

UR - http://www.scopus.com/inward/record.url?scp=0015836318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015836318&partnerID=8YFLogxK

U2 - 10.1016/0041-0101(73)90034-2

DO - 10.1016/0041-0101(73)90034-2

M3 - Article

VL - 11

SP - 361

EP - 368

JO - Toxicon

JF - Toxicon

SN - 0041-0101

IS - 4

ER -