Hypertensive responses to orthostatic and inverse-orthostatic stimuli measured by cardiovascular telemetry

L. Dézsi, G. Raffai, E. Monos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The organism is exposed to diverse orthostatic stimuli that may induce acute and chronic adaptive responses. The effects of various orthostatic stimuli on cardiovascular adaptive responses were investigated in conscious rats. Arterial blood pressure and heart rate were measured by cardiovascular telemetry. Hypertension was induced via inhibition of the NO-synthase. Orthostatic and inverse-orthostatic challenges were induced by 45° head-up (HUT) or head-down (HDT) tilt positions in tubular cages. Experimental protocols included (i.) 5 min duration repeated 3 times with 5-min pauses each "R", or (ii.) sustained tilting for 120 min "S". In normotensive rats, horizontal control blood pressure was R115.4 ± 1.4/S113.7 ± 1.6 mmHg (mean ± SEM) and heart rate R386.4 ± 7.0/S377.9 ± 8.8 BPM. HUT increased blood pressure by R

Original languageEnglish
Title of host publicationIFMBE Proceedings
Pages543-546
Number of pages4
Volume37
DOIs
Publication statusPublished - 2011

Fingerprint

Blood pressure
Telemetering
Rats
Nitric Oxide Synthase
Scanning electron microscopy

Keywords

  • cardiovascular telemetry
  • conscious rats
  • orthostatic hypertension
  • orthostatic hypotension

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Hypertensive responses to orthostatic and inverse-orthostatic stimuli measured by cardiovascular telemetry. / Dézsi, L.; Raffai, G.; Monos, E.

IFMBE Proceedings. Vol. 37 2011. p. 543-546.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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