Hypertension in thyroid disorders

Eszter Berta, Inez Lengyel, Sándor Halmi, Miklós Zrínyi, Annamária Erdei, Mariann Harangi, Dénes Páll, Endre V. Nagy, Miklós Bodor

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Arterial hypertension represents a major global health concern; more than one fourth of the population is affected by high blood pressure. Albeit the underlying cause of the disease remains unclear in the vast majority of the cases, ∼10% are of secondary origin. Endocrine disorders are common illnesses and some of them may lead to elevated blood pressure, among which thyroid diseases are of high prevalence and often overlooked, especially in mild cases. Overt and subclinical hyper- and hypothyroidism can both lead to (mostly mild) hypertension; however, the underlying mechanisms are only partially understood. The results of clinical studies are often controversial. During the past decades, some genetic mutations in the hypothalamus-pituitary-thyroid axis with cardiovascular consequences were revealed. Atherosclerotic changes resulting from lipid abnormalities due to thyroid dysfunction also affect the vasculature and can cause elevated blood pressure. The review gives a synopsis of our knowledge how thyroid hormone metabolism and functional thyroid diseases affect the cardiovascular system, their negative impact and causative role in the development of hypertension.

Original languageEnglish
Article number482
JournalFrontiers in Endocrinology
Volume10
Issue numberJULY
DOIs
Publication statusPublished - 2019

Keywords

  • Arterial stiffness
  • Blood pressure
  • Cardiovascular risk
  • Endocrine
  • Hypertension
  • Hyperthyroidism
  • Hypothyroidism
  • Thyroid

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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