Hyperoxia-induced changes in mouse lung mechanics: Forced oscillations vs. barometric plethysmography

Ferenc Peták, Walid Habre, Yves R. Donati, Zoltán Hantos, Constance Barazzone-Argiroffo

Research output: Contribution to journalArticle

94 Citations (Scopus)


Hyperoxia-induced lung damage was investigated via airway and respiratory tissue mechanics measurements with low-frequency forced oscillations (LFOT) and analysis of spontaneous breathing indexes by barometric whole body plethysmography (WBP). WBP was performed in the unrestrained awake mice kept in room air (n = 12) or in 100% oxygen for 24 (n = 9), 48 (n = 8), or 60 (n = 9) h, and the indexes, including enhanced pause (Penh) and peak inspiratory and expiratory flows, were determined. The mice were then anesthetized, paralyzed, and mechanically ventilated. Airway resistance, respiratory system resistance at breathing frequency, and tissue damping and elastance were identified from the LFOT impedance data by model fitting. The monotonous decrease in airway resistance during hyperoxia correlated best with the increasing peak expiratory flow. Respiratory system resistance and tissue damping and elastance were unchanged up to 48 h of exposure but were markedly elevated at 60 h, with associated decreases in peak inspiratory flow. Penh was increased at 24 h and sharply elevated at 60 h. These results indicate no adverse effect of hyperoxia on the airway mechanics in mice, whereas marked parenchymal damage develops by 60 h. The inconsistent relationships between LFOT parameters and WBP indexes suggest that the changes in the latter reflect alterations in the breathing pattern rather than in the mechanical properties. It is concluded that, in the presence of diffuse lung disease, Penh is inadequate for characterization of the mechanical status of the respiratory system.

Original languageEnglish
Pages (from-to)2221-2230
Number of pages10
JournalJournal of Applied Physiology
Issue number6
Publication statusPublished - Jun 1 2001


  • Airway resistance
  • Enhanced pause
  • Lung elastance
  • Respiratory mechanics

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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