Hyperleptinemia is not responsible for decreased paraoxonase activity in hemodialysis patients

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Abstract

Background: Exogenous leptin markedly decreased plasma paraoxonase (PON1) activity in rats. Hyperleptinemia and decreased PON1 activity have previously been demonstrated in uremia. Therefore, we investigated the relationship between leptin level and PON1 activity in hemodialysis (HD) patients. Methods: Leptin and PON1 were determined in 40 HD patients and 40 age-matched controls with similar body mass index (BMI). Results: Leptin was higher (p <0.001) and PON1 activity was lower (p <0.001) in HD patients than in controls. PON1 and PON1/HDL ratio was higher in HD patients with BMI >25 kg/m2 than in HD patients with BMI 2. It was not due to a difference in frequency of high activity phenotype of PON1 among subgroups of HD patients. There was no similar difference in controls. Spearman analysis showed a significant correlation between leptin and PON1 activity (p <0.02), BMI (p <0.001), triglyceride (TG) (p <0.03), and Kt/V (-0.323, p <0.03), but multiparametric regression analysis did not reveal it. PON1 activity depended on BMI in both models. In controls, leptin correlated with BMI (p <0.001) and TG (p <0.002) but not PON1 activity. A slight decrease in leptin concentration and PON1 activity during HD was observed. Conclusion: Our results suggest the role of other pathophysiological conditions besides hyperleptinemia resulting in decreased PON1 activity in HD patients.

Original languageEnglish
JournalNephron - Clinical Practice
Volume103
Issue number3
DOIs
Publication statusPublished - Jun 2006

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Aryldialkylphosphatase
Leptin
Renal Dialysis
Body Mass Index
Triglycerides
Uremia
Regression Analysis
Phenotype

Keywords

  • Hemodialysis
  • Leptin in hemodialysis
  • Paraoxonase in hemodialysis

ASJC Scopus subject areas

  • Nephrology

Cite this

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title = "Hyperleptinemia is not responsible for decreased paraoxonase activity in hemodialysis patients",
abstract = "Background: Exogenous leptin markedly decreased plasma paraoxonase (PON1) activity in rats. Hyperleptinemia and decreased PON1 activity have previously been demonstrated in uremia. Therefore, we investigated the relationship between leptin level and PON1 activity in hemodialysis (HD) patients. Methods: Leptin and PON1 were determined in 40 HD patients and 40 age-matched controls with similar body mass index (BMI). Results: Leptin was higher (p <0.001) and PON1 activity was lower (p <0.001) in HD patients than in controls. PON1 and PON1/HDL ratio was higher in HD patients with BMI >25 kg/m2 than in HD patients with BMI 2. It was not due to a difference in frequency of high activity phenotype of PON1 among subgroups of HD patients. There was no similar difference in controls. Spearman analysis showed a significant correlation between leptin and PON1 activity (p <0.02), BMI (p <0.001), triglyceride (TG) (p <0.03), and Kt/V (-0.323, p <0.03), but multiparametric regression analysis did not reveal it. PON1 activity depended on BMI in both models. In controls, leptin correlated with BMI (p <0.001) and TG (p <0.002) but not PON1 activity. A slight decrease in leptin concentration and PON1 activity during HD was observed. Conclusion: Our results suggest the role of other pathophysiological conditions besides hyperleptinemia resulting in decreased PON1 activity in HD patients.",
keywords = "Hemodialysis, Leptin in hemodialysis, Paraoxonase in hemodialysis",
author = "Z. Varga and G. Paragh and I. Seres and G. Kakuk and Z. Kar{\'a}nyi and Istvan Karpati and J. M{\'a}tyus and Eva Csongradi and A. Juh{\'a}sz and J. Balla and L. Bajnok",
year = "2006",
month = "6",
doi = "10.1159/000092020",
language = "English",
volume = "103",
journal = "Experimental Nephrology",
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TY - JOUR

T1 - Hyperleptinemia is not responsible for decreased paraoxonase activity in hemodialysis patients

AU - Varga, Z.

AU - Paragh, G.

AU - Seres, I.

AU - Kakuk, G.

AU - Karányi, Z.

AU - Karpati, Istvan

AU - Mátyus, J.

AU - Csongradi, Eva

AU - Juhász, A.

AU - Balla, J.

AU - Bajnok, L.

PY - 2006/6

Y1 - 2006/6

N2 - Background: Exogenous leptin markedly decreased plasma paraoxonase (PON1) activity in rats. Hyperleptinemia and decreased PON1 activity have previously been demonstrated in uremia. Therefore, we investigated the relationship between leptin level and PON1 activity in hemodialysis (HD) patients. Methods: Leptin and PON1 were determined in 40 HD patients and 40 age-matched controls with similar body mass index (BMI). Results: Leptin was higher (p <0.001) and PON1 activity was lower (p <0.001) in HD patients than in controls. PON1 and PON1/HDL ratio was higher in HD patients with BMI >25 kg/m2 than in HD patients with BMI 2. It was not due to a difference in frequency of high activity phenotype of PON1 among subgroups of HD patients. There was no similar difference in controls. Spearman analysis showed a significant correlation between leptin and PON1 activity (p <0.02), BMI (p <0.001), triglyceride (TG) (p <0.03), and Kt/V (-0.323, p <0.03), but multiparametric regression analysis did not reveal it. PON1 activity depended on BMI in both models. In controls, leptin correlated with BMI (p <0.001) and TG (p <0.002) but not PON1 activity. A slight decrease in leptin concentration and PON1 activity during HD was observed. Conclusion: Our results suggest the role of other pathophysiological conditions besides hyperleptinemia resulting in decreased PON1 activity in HD patients.

AB - Background: Exogenous leptin markedly decreased plasma paraoxonase (PON1) activity in rats. Hyperleptinemia and decreased PON1 activity have previously been demonstrated in uremia. Therefore, we investigated the relationship between leptin level and PON1 activity in hemodialysis (HD) patients. Methods: Leptin and PON1 were determined in 40 HD patients and 40 age-matched controls with similar body mass index (BMI). Results: Leptin was higher (p <0.001) and PON1 activity was lower (p <0.001) in HD patients than in controls. PON1 and PON1/HDL ratio was higher in HD patients with BMI >25 kg/m2 than in HD patients with BMI 2. It was not due to a difference in frequency of high activity phenotype of PON1 among subgroups of HD patients. There was no similar difference in controls. Spearman analysis showed a significant correlation between leptin and PON1 activity (p <0.02), BMI (p <0.001), triglyceride (TG) (p <0.03), and Kt/V (-0.323, p <0.03), but multiparametric regression analysis did not reveal it. PON1 activity depended on BMI in both models. In controls, leptin correlated with BMI (p <0.001) and TG (p <0.002) but not PON1 activity. A slight decrease in leptin concentration and PON1 activity during HD was observed. Conclusion: Our results suggest the role of other pathophysiological conditions besides hyperleptinemia resulting in decreased PON1 activity in HD patients.

KW - Hemodialysis

KW - Leptin in hemodialysis

KW - Paraoxonase in hemodialysis

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U2 - 10.1159/000092020

DO - 10.1159/000092020

M3 - Article

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VL - 103

JO - Experimental Nephrology

JF - Experimental Nephrology

SN - 0028-2766

IS - 3

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